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Uroguanylin (GUCA2B) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS316771

MBS316771 is an antibody targeting GUCA2B. Also known as Rabbit anti Uroguanylin. Reactive in Human. Host: Rabbit. More details

$510 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Uroguanylin (GUCA2B), Polyclonal Antibody
Full Product Name
Rabbit anti Uroguanylin
Product Gene Name
Product Synonym Names
Rabbit Antibody to Human Uroguanylin
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Neat, Lyophilized. Reconstitute in 20ul double distilled water.
Specificity
Uroguanylin (a.a.1-8) circulating form (Human Uroguanylin (a.a. 1-8) circulating form)
Preparation and Storage
Store lyophilized product at 2-8 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles.
Molecular Weight
12,069 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (42619092..42621495). Location: 1p34-p33
OMIM
601271
3D Structure
ModBase 3D Structure for Q16661
Preservative
No Preservative
Immunogen
Synthetic human Uroguanylin (a.a. 1-8) circulating form (FKTLRTIA)
Buffer
Not applicable
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-GUCA2B antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Radioimmunoassay (RIA)
Application Notes for anti-GUCA2B antibody
Suitable for use in RIA (1:10,000), ELISA (1:2,000), Western blot (1:1,000) and Immunohistochemistry (acrylic resin, 1:800).

Product References and Citations for anti-GUCA2B antibody

1. Hess, R., et al., (1995), "GCAP-II: isolation and characterization of the circulating form of human uroguanylin", FEBS Lett., 374(1): 34-38
2. Mägert, H-J., et al., (1998), "Uroguanylin: Gene structure, expression, processing as a peptide hormone, and co-storage with somatostatin in gastrointestinal D-cells" Regul. Pept., 73(3): 165-176

Other Notes

Small volumes of anti-GUCA2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GUCA2B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
uroguanylin
NCBI Official Synonym Full Names
guanylate cyclase activator 2B (uroguanylin)
NCBI Official Symbol
GUCA2B
NCBI Official Synonym Symbols
UGN; GCAP-II
UniProt Protein Name
Guanylate cyclase activator 2B
UniProt Synonym Protein Names
Guanylate cyclase C-activating peptide II
UniProt Gene Name
GUCA2B
UniProt Synonym Gene Names
GCAP-II; UGN
UniProt Entry Name
GUC2B_HUMAN
NCBI Protein Information
guanylate cyclase activator 2B; uroguanylin

NCBI Summary for GUCA2B

This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues. [provided by RefSeq, Oct 2011]
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UniProt Comments for GUCA2B

Function: Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.

Subcellular location: Secreted.

Tissue specificity: Stomach and intestine.

Sequence similarities: Belongs to the guanylin family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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