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L3MBTL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3200157

This is a rabbit polyclonal antibody against L3MBTL2. It was validated on Western Blot and immunohistochemistryTarget Description: L3MBTL2 contains 1 FCS-type zinc finger and 4 MBT repeats. It is putative Polycomb group (PcG) protein. PcG proteins maintain… More details

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Product Overview

Online Datasheet in PDF
Product Name
L3MBTL2, Polyclonal Antibody
Full Product Name
L3MBTL2 antibody - C-terminal region
Product Gene Name
anti-L3MBTL2 antibody
Product Synonym Gene Name
H-l(3)mbt-l; L3MBT
Immunogen Sequence
Synthetic peptide located within the following region: EYDQWVDCES PDIYPVGWCE LTGYQLQPPV AAEPATPLKA KEATKKKKKQ
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Protein A purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
L3MBTL2 peptide (MBS3224845) is used for blocking the activity of L3MBTL2 antibody (MBS3200157)
Molecular Weight
79kDa
OMIM
611865
3D Structure
ModBase 3D Structure for Q969R5
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 80%; Rabbit: 100%; Rat: 86%
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human L3MBTL2

Product Categories/Family for anti-L3MBTL2 antibody

Polyclonal; Transcription Factor; Transcription Regulation; Transcription Regulation; Chromatin & Nuclear Signaling; Epigenetics; Meiosis/Mitosis/Cell Cycle; Immunohistochemistry; Transcription Factors
Applications Tested/Suitable for anti-L3MBTL2 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-L3MBTL2 antibody

Rabbit Anti-L3MBTL2 Antibody
Paraffin Embedded Tissue: Human Kidney
Cellular Data: Epithelial cells of renal tubule
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
Rabbit Anti-L3MBTL2 Polyclonal Antibody – Cat# MBS3200157

Western Blot (WB) of anti-L3MBTL2 antibody

WB Suggested Anti-L3MBTL2 Antibody Titration: 0.625ug/ml
ELISA Titer: 1:312500
Positive Control: Transfected 293T
Rabbit Anti-L3MBTL2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3200157

Other Notes

Small volumes of anti-L3MBTL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L3MBTL2 purchase

MBS3200157 is an antibody targeting L3MBTL2. Also known as L3MBTL2 antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for L3MBTL2. It may not necessarily be applicable to this product.

NCBI GI #
20149698
NCBI GeneID
83746
NCBI Accession #
NP_113676
UniProt Primary Accession #
Q969R5
UniProt Related Accession #
Q969R5
GenBank Nucleotide #
NM_031488
NCBI Official Full Name
lethal(3)malignant brain tumor-like protein 2
NCBI Official Synonym Full Names
L3MBTL histone methyl-lysine binding protein 2
NCBI Official Symbol
L3MBTL2
NCBI Official Synonym Symbols
L3MBT; H-l(3)mbt-l
UniProt Protein Name
Lethal(3)malignant brain tumor-like protein 2
Protein Family
Lethal(3)malignant brain tumor-like protein
UniProt Gene Name
L3MBTL2
UniProt Synonym Gene Names
H-l(3)mbt-like protein 2
UniProt Entry Name
LMBL2_HUMAN
NCBI Protein Information
lethal(3)malignant brain tumor-like protein 2

UniProt Comments for L3MBTL2

Function: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Ref.12

Subunit structure: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.

Subcellular location: Nucleus

Probable.

Sequence similarities: Contains 1 FCS-type zinc finger.Contains 4 MBT repeats.

Sequence caution: The sequence BAB84917.1 differs from that shown. Reason: Intron retention.The sequence BAC04936.1 differs from that shown. Reason: Intron retention.
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Research Articles on L3MBTL2

1. L3MBTL2 polymorphism is associated with neuroticism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-L3MBTL2 antibody

 Reference Product  PubMed Publications
 E2F6 antibody  >3 publications with L3MBTL2 and E2F6
 HDAC3 antibody  >1 publications with L3MBTL2 and HDAC3
 RB1 antibody  >1 publications with L3MBTL2 and RB1
 PCGF6 antibody  >1 publications with L3MBTL2 and PCGF6
 CBX3 antibody  >1 publications with L3MBTL2 and CBX3

Organs/Tissues associated with anti-L3MBTL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with L3MBTL2 and Brain
 Bone Antibodies  >1 publications with L3MBTL2 and Bone
 Bone Marrow Antibodies  >1 publications with L3MBTL2 and Bone Marrow
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