Rabbit Anti-ELK4 Polyclonal Antibody – Cat# MBS3200369

WB Suggested Anti-ELK4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B cell lysateELK4 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells

ELK4 Antibody – Rabbit Polyclonal

Name: ELK4 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3200369
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3200369

This is a rabbit polyclonal antibody against ELK4. It was validated on Western BlotTarget Description: The ELK4 gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ELK4, Polyclonal Antibody

Full Product Name

ELK4 antibody - C-terminal region

Product Gene Name

anti-ELK4 antibody

Product Synonym Gene Name

SAP1

Immunogen Sequence

Synthetic peptide located within the following region: ASLTPAFFSQ VACSLFMVSP LLSFICPFKQ IQNLYTQVCF LLLRFVLERL

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

ELK4 peptide (MBS3225369) is used for blocking the activity of ELK4 antibody (MBS3200369)

Molecular Weight

45kDa

OMIM

M85165 mRNA

3D Structure

ModBase 3D Structure for P28324

Homology

Human: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human ELK4

Product Categories/Family for anti-ELK4 antibody

Polyclonal; Transcription Factor; Transcription Regulation; Transcription Regulation; Cell Biology; Signal Transduction; DNA/RNA/Protein Interactions; Transcription Factors

Applications Tested/Suitable for anti-ELK4 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-ELK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ELK4 purchase

MBS3200369 is an antibody targeting ELK4. Also known as ELK4 antibody - C-terminal region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ELK4. It may not necessarily be applicable to this product.

NCBI GI #

11496882

NCBI GeneID

2005

NCBI Accession #

NP_068567

UniProt Primary Accession #

P28324

UniProt Related Accession #

P28324

GenBank Nucleotide #

NM_021795

NCBI Official Full Name

ETS domain-containing protein Elk-4 isoform b

NCBI Official Synonym Full Names

ETS transcription factor ELK4

NCBI Official Symbol

ELK4

NCBI Official Synonym Symbols

SAP1

UniProt Protein Name

ETS domain-containing protein Elk-4

UniProt Synonym Protein Names

Serum response factor accessory protein 1; SAP-1; SRF accessory protein 1

Protein Family

ETS domain-containing protein

UniProt Gene Name

ELK4

UniProt Synonym Gene Names

SAP1; SAP-1; SRF accessory protein 1

NCBI Protein Information

ETS domain-containing protein Elk-4

NCBI Summary for ELK4

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for ELK4

Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously.

Research Articles on ELK4

1. Data suggest that SIRT7 undergoes Lys-63 polyubiquitination, later removed by USP7 to repress enzymatic activity of SIRT7; USP7 and SIRT7 regulate gluconeogenesis via expression of glucose-6-phosphatase catalytic subunit (G6PC); SIRT7 targets G6PC promoter through ELK4. (SIRT7 = sirtuin 7; USP7 = ubiquitin specific peptidase 7; G6PC = glucose-6-phosphatase catalytic subunit; ELK4 = transcription factor ELK4)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.