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SPIC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3200810

This is a rabbit polyclonal antibody against SPIC. It was validated on Western BlotTarget Description: SPIC controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SPIC, Polyclonal Antibody
Full Product Name
SPIC antibody - C-terminal region
Product Gene Name
Product Synonym Gene Name
MGC40611; SPI-C
Immunogen Sequence
Synthetic peptide located within the following region: EKLAELWGKR KGNRKTMTYQ KMARALRNYG RSGEITKIRR KLTYQFSEAI
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
SPIC peptide (MBS3225852) is used for blocking the activity of SPIC antibody (MBS3200810)
Molecular Weight
29kDa
OMIM
612568
3D Structure
ModBase 3D Structure for Q8N5J4
Homology
Cow: 93%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 85%
Applications Tested/Suitable for anti-SPIC antibody
Western Blot (WB)

Western Blot (WB) of anti-SPIC antibody

Host: Rabbit
Target Name: SPIC
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 1ug/ml
Rabbit Anti-SPIC Polyclonal Antibody – Cat# MBS3200810

Western Blot (WB) of anti-SPIC antibody

WB Suggested Anti-SPIC Antibody
Titration: 1.0 ug/ml
Positive Control: ACHN Whole Cell
Rabbit Anti-SPIC Polyclonal Antibody, Western Blot (WB) – Cat# MBS3200810

Other Notes

Small volumes of anti-SPIC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPIC purchase

MBS3200810 is an antibody targeting SPIC. Also known as SPIC antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SPIC. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
transcription factor Spi-C
NCBI Official Synonym Full Names
Spi-C transcription factor
NCBI Official Symbol
SPIC
NCBI Official Synonym Symbols
SPI-C
UniProt Protein Name
Transcription factor Spi-C
UniProt Gene Name
SPIC
UniProt Entry Name
SPIC_HUMAN
NCBI Protein Information
transcription factor Spi-C

NCBI Summary for SPIC

The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]

UniProt Comments for SPIC

SPIC: Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-rich DNA sequence (5'-GAGGA[AT]-3') that can act as a lymphoid-specific enhancer. Regulates VCAM1 gene expression. Belongs to the ETS family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: nucleus

Molecular Function: sequence-specific DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; blastocyst development; positive regulation of transcription from RNA polymerase II promoter; cell differentiation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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