Rabbit Anti-SP3 Polyclonal Antibody – Cat# MBS3201458

Host: Rabbit
Target Name: SP3
Sample Type: RPMI-8226 Whole Cell lysates
Antibody Dilution: 1.0ug/ml

SP3 Antibody – Rabbit Polyclonal

Name: SP3 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3201458
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3201458

This is a rabbit polyclonal antibody against SP3. It was validated on Western BlotTarget Description: This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SP3, Polyclonal Antibody

Full Product Name

SP3 Antibody - N-terminal region

Product Gene Name

anti-SP3 antibody

Immunogen Sequence

Synthetic peptide located within the following region: SSSSQLPVTI DSTGILQQNT NSLTTSSGQV HSSDLQGNYI QSPVSEETQA

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

SP3 peptide (MBS3226474) is used for blocking the activity of SP3 antibody (MBS3201458)

Molecular Weight

52kDa

OMIM

601804

3D Structure

ModBase 3D Structure for Q02447

Homology

Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%

Immunogen

The immunogen is a synthetic peptide directed towards the N-terminal region of Human SP3

Product Categories/Family for anti-SP3 antibody

Polyclonal; Transcription Factor; Transcription Regulation; Cell Biology; DNA/RNA/Protein Interactions

Applications Tested/Suitable for anti-SP3 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-SP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SP3 purchase

MBS3201458 is an antibody targeting SP3. Also known as SP3 Antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SP3. It may not necessarily be applicable to this product.

NCBI GI #

289577125

NCBI GeneID

6670

NCBI Accession #

NP_001017371.3

UniProt Primary Accession #

Q02447

UniProt Related Accession #

Q02447

GenBank Nucleotide #

NM_001017371.4

NCBI Official Full Name

transcription factor Sp3 isoform 2

NCBI Official Synonym Full Names

Sp3 transcription factor

NCBI Official Symbol

SP3

NCBI Official Synonym Symbols

SPR2

UniProt Protein Name

Transcription factor Sp3

UniProt Synonym Protein Names

SPR-2

Protein Family

Transcription factor

UniProt Gene Name

SP3

UniProt Entry Name

SP3_HUMAN

NCBI Protein Information

transcription factor Sp3

NCBI Summary for SP3

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010]

UniProt Comments for SP3

Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping.

Research Articles on SP3

1. expression of the nearby cyclindependent kinase inhibitor 1C (CDKN1C) gene was revealed to be upregulated after SP3 knockdown in cells that possessed non-risk alleles. This suggests that CDKN1C is potentially one of the functional targets of SNP rs163184, which modulates the binding activity of the locus for Sp3 and Lsd1/Kdm1a

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SP3 antibody

Reference Product	PubMed Publications
SP1 antibody	>1305 publications with SP3 and SP1
CDKN1A antibody	>44 publications with SP3 and CDKN1A
HDAC1 antibody	>34 publications with SP3 and HDAC1
HDAC2 antibody	>22 publications with SP3 and HDAC2
SMAD3 antibody	>17 publications with SP3 and SMAD3
TP53 antibody	>7 publications with SP3 and TP53
EP300 antibody	>3 publications with SP3 and EP300
NFATC1 antibody	>2 publications with SP3 and NFATC1
ESR1 antibody	>1 publications with SP3 and ESR1

Pathways associated with anti-SP3 antibody

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Regulation Of Telomerase Pathway antibodies	Regulation Of Telomerase Pathway Diagram
SIDS Susceptibility Pathways antibodies	SIDS Susceptibility Pathways Diagram
SUMO E3 Ligases SUMOylate Target Proteins Pathway antibodies	SUMO E3 Ligases SUMOylate Target Proteins Pathway Diagram
SUMOylation Pathway antibodies	SUMOylation Pathway Diagram
SUMOylation Of Transcription Factors Pathway antibodies	SUMOylation Of Transcription Factors Pathway Diagram
Selenium Metabolism And Selenoproteins Pathway antibodies	Selenium Metabolism And Selenoproteins Pathway Diagram

Diseases associated with anti-SP3 antibody

Disease Name	Pubmed Publications
Breast Neoplasms Antibodies	>58 publications with SP3 and Breast Neoplasms
Nervous System Diseases Antibodies	>49 publications with SP3 and Nervous System Diseases
Necrosis Antibodies	>40 publications with SP3 and Necrosis
Liver Diseases Antibodies	>37 publications with SP3 and Liver Diseases
Inflammation Antibodies	>32 publications with SP3 and Inflammation
Liver Neoplasms Antibodies	>28 publications with SP3 and Liver Neoplasms
Neoplasms, Experimental Antibodies	>27 publications with SP3 and Neoplasms, Experimental
Fibrosis Antibodies	>24 publications with SP3 and Fibrosis
Carcinoma, Hepatocellular Antibodies	>23 publications with SP3 and Carcinoma, Hepatocellular
Pancreatic Neoplasms Antibodies	>22 publications with SP3 and Pancreatic Neoplasms

Organs/Tissues associated with anti-SP3 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>160 publications with SP3 and Blood
Brain Antibodies	>108 publications with SP3 and Brain
Vascular Antibodies	>107 publications with SP3 and Vascular
Liver Antibodies	>101 publications with SP3 and Liver
Muscle Antibodies	>99 publications with SP3 and Muscle
Lung Antibodies	>93 publications with SP3 and Lung
Heart Antibodies	>54 publications with SP3 and Heart
Skin Antibodies	>53 publications with SP3 and Skin
Embryonic Tissue Antibodies	>48 publications with SP3 and Embryonic Tissue
Kidney Antibodies	>45 publications with SP3 and Kidney