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VPS72 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3201464

This is a rabbit polyclonal antibody against VPS72. It was validated on Western Blot using a cell lysate as a positive control.Target Description: VPS72 could be a DNA-binding transcriptional regulator. VPS72 may be involved in chromatin modification and… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
VPS72, Polyclonal Antibody
Full Product Name
VPS72 antibody - N-terminal region
Product Gene Name
Product Synonym Gene Name
Swc2; TCFL1; YL-1; YL1; CFL1
Immunogen Sequence
Synthetic peptide located within the following region: GGFTEESGDD EYQGDQSDTE DEVDSDFDID EGDEPSSDGE AEEPRRKRRV
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
VPS72 peptide (MBS3226480) is used for blocking the activity of VPS72 antibody (MBS3201464)
Molecular Weight
40kDa
OMIM
600607
3D Structure
ModBase 3D Structure for Q15906
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 77%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human VPS72
Applications Tested/Suitable for anti-VPS72 antibody
Western Blot (WB)

Western Blot (WB) of anti-VPS72 antibody

WB Suggested Anti-VPS72 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:2500
Positive Control: ACHN cell lysate
Rabbit Anti-VPS72 Polyclonal Antibody – Cat# MBS3201464

Other Notes

Small volumes of anti-VPS72 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VPS72 purchase

MBS3201464 is an antibody targeting VPS72. Also known as VPS72 antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS72. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
vacuolar protein sorting-associated protein 72 homolog isoform 2
NCBI Official Synonym Full Names
vacuolar protein sorting 72 homolog
NCBI Official Symbol
VPS72
NCBI Official Synonym Symbols
YL1; CFL1; Swc2; YL-1; TCFL1
UniProt Protein Name
Vacuolar protein sorting-associated protein 72 homolog
UniProt Synonym Protein Names
Protein YL-1; Transcription factor-like 1
UniProt Gene Name
VPS72
UniProt Synonym Gene Names
TCFL1; YL1
UniProt Entry Name
VPS72_HUMAN
NCBI Protein Information
vacuolar protein sorting-associated protein 72 homolog

NCBI Summary for VPS72

The protein encoded by this gene is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
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UniProt Comments for VPS72

VPS72: Could be a DNA-binding transcriptional regulator. May be involved in chromatin modification and remodeling. Belongs to the VPS72/YL1 family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; protein complex; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; somatic stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; chromatin modification
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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