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PTHLH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3201775

This is a rabbit polyclonal antibody against Pthlh. It was validated on Western BlotTarget Description: Pthlh is a neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of… More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Pthlh, Polyclonal Antibody
Full Product Name
Pthlh antibody - middle region
Product Gene Name
anti-PTHLH antibody
Product Synonym Gene Name
PTH-like; Pthrp
Immunogen Sequence
Synthetic peptide located within the following region: EVSPNSKPAP NTKNHPVRFG SDDEGRYLTQ ETNKVETYKE QPLKTPGKKK
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
Pthlh peptide (MBS3226778) is used for blocking the activity of Pthlh antibody (MBS3201775)
Molecular Weight
16kDa
3D Structure
ModBase 3D Structure for P22858
Homology
Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 85%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
Immunogen
The immunogen is a synthetic peptide corresponding to a region of Mouse

Product Categories/Family for anti-PTHLH antibody

Polyclonal; Transcription Factor; Transcription Regulation; Transcription Regulation; Cell Biology; Immunohistochemistry; GPCR; Transcription Factors; Cell Differentiation
Applications Tested/Suitable for anti-PTHLH antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-PTHLH antibody

Immunohistochemistry with Lung tissue at an antibody concentration of 5ug/ml using anti-Pthlh antibody
Rabbit Anti-PTHLH Polyclonal Antibody – Cat# MBS3201775

Western Blot (WB) of anti-PTHLH antibody

WB Suggested Anti-Pthlh Antibody Titration: 1 ug/ml
Positive Control: Mouse Brain lysate
Rabbit Anti-PTHLH Polyclonal Antibody, Western Blot (WB) – Cat# MBS3201775

Other Notes

Small volumes of anti-PTHLH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTHLH purchase

MBS3201775 is an antibody targeting PTHLH. Also known as Pthlh antibody - middle region. Reactive in Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTHLH. It may not necessarily be applicable to this product.

NCBI GI #
148747356
NCBI GeneID
19227
NCBI Accession #
NP_032996
UniProt Primary Accession #
P22858
UniProt Related Accession #
P22858
GenBank Nucleotide #
NM_008970
NCBI Official Full Name
parathyroid hormone-related protein preproprotein
NCBI Official Synonym Full Names
parathyroid hormone-like peptide
NCBI Official Symbol
Pthlh
NCBI Official Synonym Symbols
PLP; Pthrp; PTH-like
UniProt Protein Name
Parathyroid hormone-related protein
UniProt Synonym Protein Names
Parathyroid hormone-like protein; PLP
Protein Family
Parathyroid hormone-related protein
UniProt Gene Name
Pthlh
UniProt Synonym Gene Names
Pthrp; PTH-rP; PTHrP; PLP
NCBI Protein Information
parathyroid hormone-related protein

NCBI Summary for PTHLH

This gene encodes a member of the parathyroid family of hormones that possesses distinct paracrine and intracrine signaling roles such as regulation of circulating calcium, transplacental calcium transport, osteoclast inhibition, renal bicarbonate excretion and regulation of apoptosis. The encoded protein undergoes proteolytic processing to generate multiple active peptides with distinct signaling functions. The homozygous deletion of this gene leads to death shortly after birth with a chondrodystrophic phenotype characterized by premature chondrocyte differentiation and accelerated bone formation. [provided by RefSeq, Jul 2015]
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UniProt Comments for PTHLH

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
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Research Articles on PTHLH

1. PTHrP expression is required for normal morphological development of the placenta.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTHLH antibody

 Reference Product  PubMed Publications
 Ihh antibody  >26 publications with PTHLH and Ihh
 Pth1r antibody  >19 publications with PTHLH and Pth1r
 Runx2 antibody  >8 publications with PTHLH and Runx2
 Pth2r antibody  >4 publications with PTHLH and Pth2r
 Ibsp antibody  >3 publications with PTHLH and Ibsp
 Gnas antibody  >1 publications with PTHLH and Gnas
 Ptger4 antibody  >1 publications with PTHLH and Ptger4

Pathways associated with anti-PTHLH antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Organs/Tissues associated with anti-PTHLH antibody

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >222 publications with PTHLH and Other
 Lung Antibodies  >132 publications with PTHLH and Lung
 Skin Antibodies  >72 publications with PTHLH and Skin
 Embryonic Tissue Antibodies  >62 publications with PTHLH and Embryonic Tissue
 Mammary Gland Antibodies  >32 publications with PTHLH and Mammary Gland
 Brain Antibodies  >28 publications with PTHLH and Brain
 Ovary Antibodies  >15 publications with PTHLH and Ovary
 Bladder Antibodies  >9 publications with PTHLH and Bladder
 Extraembryonic Tissue Antibodies  >5 publications with PTHLH and Extraembryonic Tissue
 Thymus Antibodies  >4 publications with PTHLH and Thymus
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