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KCNQ1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3202361

This is a rabbit polyclonal antibody against KCNQ1. It was validated on Western Blot using a cell lysate as a positive control.Target Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
KCNQ1, Polyclonal Antibody
Full Product Name
KCNQ1 antibody - N-terminal region
Product Gene Name
anti-KCNQ1 antibody
Product Synonym Gene Name
ATFB1; FLJ26167; JLNS1; KCNA8; KCNA9; KVLQT1; Kv1.9; Kv7.1; LQT; LQT1; RWS; SQT2; WRS; ATFB3
Immunogen Sequence
Synthetic peptide located within the following region: RSKYVGLWGR LRFARKPISI IDLIVVVASM VVLCVGSKGQ VFATSAIRGI
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
KCNQ1 peptide (MBS3227339) is used for blocking the activity of KCNQ1 antibody (MBS3202361)
Molecular Weight
64kDa
OMIM
192500
3D Structure
ModBase 3D Structure for P51787
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human KCNQ1

Product Categories/Family for anti-KCNQ1 antibody

Polyclonal; Cardiovascular; Stem Cells; Immunohistochemistry
Applications Tested/Suitable for anti-KCNQ1 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-KCNQ1 antibody

Kidney
Rabbit Anti-KCNQ1 Polyclonal Antibody – Cat# MBS3202361

Western Blot (WB) of anti-KCNQ1 antibody

Host: Mouse
Target Name: KCNQ1
Sample Tissue: Mouse Brain
Antibody Dilution: 1ug/ml
Rabbit Anti-KCNQ1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3202361

Western Blot (WB) of anti-KCNQ1 antibody

Lanes:
100 ug CHO cell lysate
Primary Antibody Dilution:
1:1000
Secondary Antibody:
Goat anti-rabbit HRP
Secondary Antibody Dilution:
1:25000
Gene Name:
KCNQ1
Submitted by:
Anonymous
Rabbit Anti-KCNQ1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3202361

Western Blot (WB) of anti-KCNQ1 antibody

WB Suggested Anti-KCNQ1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Liver
Rabbit Anti-KCNQ1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3202361

Other Notes

Small volumes of anti-KCNQ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNQ1 purchase

MBS3202361 is an antibody targeting KCNQ1. Also known as KCNQ1 antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNQ1. It may not necessarily be applicable to this product.

NCBI GI #
32479523
NCBI GeneID
3784
NCBI Accession #
NP_861462
UniProt Primary Accession #
P51787
UniProt Related Accession #
P51787
GenBank Nucleotide #
NM_181797
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily Q member 1
NCBI Official Symbol
KCNQ1
NCBI Official Synonym Symbols
LQT; RWS; WRS; LQT1; SQT2; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 1
UniProt Synonym Protein Names
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNQ1
UniProt Synonym Gene Names
KCNA8; KCNA9; KVLQT1
UniProt Entry Name
KCNQ1_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 1

NCBI Summary for KCNQ1

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
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Research Articles on KCNQ1

1. The exon sequencing results of KCNQ1 gene in 2 Xinjiang Uygur congenital long LQT1 families showed that exon16 missense changes (133G to A (G45S)) can lead to amino acid mutation, this mutation may be a pathogenic mutation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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