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TBPL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3202733

This is a rabbit polyclonal antibody against TBPL1. It was validated on Western Blot and immunohistochemistryTarget Description: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that… More details

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Product Overview

Online Datasheet in PDF
Product Name
TBPL1, Polyclonal Antibody
Full Product Name
TBPL1 antibody - middle region
Product Gene Name
anti-TBPL1 antibody
Product Synonym Gene Name
TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620
Immunogen Sequence
Synthetic peptide located within the following region: LQKLGFQVIF TDFKVVNVLA VCNMPFEIRL PEFTKNNRPH ASYEPELHPA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Protein A purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
TBPL1 peptide (MBS3227712) is used for blocking the activity of TBPL1 antibody (MBS3202733)
Molecular Weight
21kDa
OMIM
605521
3D Structure
ModBase 3D Structure for P62380
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human TBPL1

Product Categories/Family for anti-TBPL1 antibody

Polyclonal; Transcription Factor; Transcription Regulation; Developmental Biology; Signal Transduction; DNA/RNA/Protein Interactions; Immunohistochemistry; Transcription Factors
Applications Tested/Suitable for anti-TBPL1 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-TBPL1 antibody

Human kidney
Rabbit Anti-TBPL1 Polyclonal Antibody – Cat# MBS3202733

Western Blot (WB) of anti-TBPL1 antibody

WB Suggested Anti-TBPL1 Antibody Titration: 1.25ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
Rabbit Anti-TBPL1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3202733

Other Notes

Small volumes of anti-TBPL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TBPL1 purchase

MBS3202733 is an antibody targeting TBPL1. Also known as TBPL1 antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TBPL1. It may not necessarily be applicable to this product.

NCBI GI #
4759234
NCBI GeneID
9519
NCBI Accession #
NP_004856
UniProt Primary Accession #
P62380
UniProt Related Accession #
P62380
GenBank Nucleotide #
NM_004865
NCBI Official Full Name
TATA box-binding protein-like protein 1
NCBI Official Synonym Full Names
TATA-box binding protein like 1
NCBI Official Symbol
TBPL1
NCBI Official Synonym Symbols
TLF; TLP; STUD; TRF2; MGC:8389; MGC:9620
UniProt Protein Name
TATA box-binding protein-like protein 1
UniProt Synonym Protein Names
21 kDa TBP-like protein; Second TBP of unique DNA protein; STUD; TATA box-binding protein-related factor 2; TBP-related factor 2; TBP-like factor; TBP-related protein
Protein Family
TATA box-binding protein-like protein
UniProt Gene Name
TBPL1
UniProt Synonym Gene Names
TLF; TLP; TLP21; TRF2; TRP; TBP-like protein 1; STUD; TBP-related factor 2
UniProt Entry Name
TBPL1_HUMAN
NCBI Protein Information
TATA box-binding protein-like protein 1

NCBI Summary for TBPL1

This gene encodes a member of the TATA box-binding protein family. TATA box-binding proteins play a critical role in transcription by RNA polymerase II as components of the transcription factor IID (TFIID) complex. The encoded protein does not bind to the TATA box and initiates transcription from TATA-less promoters. This gene plays a critical role in spermatogenesis, and single nucleotide polymorphisms in this gene may be associated with male infertility. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Nov 2011]
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UniProt Comments for TBPL1

TBPL1: Does not bind the TATA box. Has DNA-binding ability. Belongs to the TBP family.

Protein type: Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: cytoplasm; transcription factor TFIIA complex

Molecular Function: DNA binding; transcription coactivator activity

Biological Process: acrosome formation; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription initiation; spermatid nuclear differentiation; dTTP biosynthetic process
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Research Articles on TBPL1

1. TLP Prevents p53 Degradation through Disrupting the p53-MDM2 Interaction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TBPL1 antibody

 Reference Product  PubMed Publications
 TBP antibody  >14 publications with TBPL1 and TBP
 TBPL2 antibody  >2 publications with TBPL1 and TBPL2
 FOS antibody  >1 publications with TBPL1 and FOS

Pathways associated with anti-TBPL1 antibody

 Products by Pathway  Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Basal Transcription Factors Pathway antibodies  Basal Transcription Factors Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram
 Huntington's Disease Pathway antibodies  Huntington's Disease Pathway Diagram

Diseases associated with anti-TBPL1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >1 publications with TBPL1 and Adenocarcinoma

Organs/Tissues associated with anti-TBPL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >4 publications with TBPL1 and Testis
 Embryonic Tissue Antibodies  >1 publications with TBPL1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with TBPL1 and Kidney
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