Rabbit Anti-SHPRH Polyclonal Antibody – Cat# MBS3203176

WB Suggested Anti-SHPRH Antibody Titration: 0.2-1 ug/ml
Positive Control: Hela cell lysate

SHPRH Antibody – Rabbit Polyclonal

Name: SHPRH Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3203176
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3203176

This is a rabbit polyclonal antibody against SHPRH. It was validated on Western Blot using a cell lysate as a positive control.Target Description: SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins,… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SHPRH, Polyclonal Antibody

Full Product Name

SHPRH antibody - N-terminal region

Product Gene Name

anti-SHPRH antibody

Product Synonym Gene Name

FLJ27258; FLJ37625; FLJ45012; FLJ90837; KIAA2023; MGC134886; bA545I5.2

Immunogen Sequence

Synthetic peptide located within the following region: SIIPDVLEED EDDPESEPEG QDIDELYHFV KQTHQQETQS IQVDVQHPAL

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

SHPRH peptide (MBS3228149) is used for blocking the activity of SHPRH antibody (MBS3203176)

Molecular Weight

190kDa

OMIM

608048

3D Structure

ModBase 3D Structure for Q149N8

Homology

Cow: 92%; Dog: 92%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SHPRH

Product Categories/Family for anti-SHPRH antibody

Polyclonal; RNA Binding Proteins; Cell Biology; Chromatin & Nuclear Signaling; DNA/RNA/Protein Interactions; DNA Repair

Applications Tested/Suitable for anti-SHPRH antibody

Western Blot (WB)

Other Notes

Small volumes of anti-SHPRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SHPRH purchase

MBS3203176 is an antibody targeting SHPRH. Also known as SHPRH antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SHPRH. It may not necessarily be applicable to this product.

NCBI GI #

27436873

NCBI GeneID

257218

NCBI Accession #

NP_775105

UniProt Primary Accession #

Q149N8

UniProt Related Accession #

Q149N8

GenBank Nucleotide #

NM_173082

NCBI Official Full Name

E3 ubiquitin-protein ligase SHPRH isoform b

NCBI Official Synonym Full Names

SNF2 histone linker PHD RING helicase

NCBI Official Symbol

SHPRH

NCBI Official Synonym Symbols

bA545I5.2

UniProt Protein Name

E3 ubiquitin-protein ligase SHPRH

UniProt Synonym Protein Names

SNF2, histone-linker, PHD and RING finger domain-containing helicase

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

SHPRH

UniProt Synonym Gene Names

KIAA2023

UniProt Entry Name

SHPRH_HUMAN

NCBI Protein Information

E3 ubiquitin-protein ligase SHPRH

NCBI Summary for SHPRH

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]

UniProt Comments for SHPRH

SHPRH: E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. Belongs to the SNF2/RAD54 helicase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 3.6.4.-; EC 3.6.1.-; EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating system; Helicase; Ligase

Chromosomal Location of Human Ortholog: 6q24.3

Cellular Component: nucleosome; nucleus

Molecular Function: DNA binding; zinc ion binding; ubiquitin-protein ligase activity; helicase activity; ATP binding; ligase activity

Biological Process: nucleosome assembly; protein polyubiquitination; DNA repair

Research Articles on SHPRH

1. This study suggests that SHPRH could be a link between mTOR-mediated epigenetic regulations and rRNA transcription, while concomitantly affecting genomic integrity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SHPRH antibody

Disease Name	Pubmed Publications
Anemia Antibodies	>1 publications with SHPRH and Anemia
Neoplasm Metastasis Antibodies	>1 publications with SHPRH and Neoplasm Metastasis
Lung Diseases Antibodies	>1 publications with SHPRH and Lung Diseases
Chromosome Aberrations Antibodies	>1 publications with SHPRH and Chromosome Aberrations
Lung Neoplasms Antibodies	>1 publications with SHPRH and Lung Neoplasms

Organs/Tissues associated with anti-SHPRH antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with SHPRH and Blood
Lung Antibodies	>1 publications with SHPRH and Lung