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THRB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3203847

This is a rabbit polyclonal antibody against THRB. It was validated on Western Blot using a cell lysate as a positive control.Target Description: THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone,… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
THRB, Polyclonal Antibody
Full Product Name
THRB antibody - middle region
Product Gene Name
anti-THRB antibody
Product Synonym Gene Name
ERBA-BETA; ERBA2; GRTH; MGC126109; MGC126110; NR1A2; THR1; THRB1; THRB2; PRTH; C-ERBA-2; C-ERBA-BETA
Immunogen Sequence
Synthetic peptide located within the following region: YQDSFLLAFE HYINYRKHHV THFWPKLLMK VTDLRMIGAC HASRFLHMKV
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
THRB peptide (MBS3228815) is used for blocking the activity of THRB antibody (MBS3203847)
Molecular Weight
53kDa
OMIM
145650
3D Structure
ModBase 3D Structure for P10828
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 86%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human THRB

Product Categories/Family for anti-THRB antibody

Polyclonal; Transcription Factor; Transcription Regulation; Transcription Regulation; Chromatin & Nuclear Signaling; Disease Related; Receptors; Transcription Factors
Applications Tested/Suitable for anti-THRB antibody
Western Blot (WB)

Western Blot (WB) of anti-THRB antibody

Host: Rabbit
Target Name: THRB
Sample Type: 721_B
Antibody Dilution: 1.0ug/mlTHRB is supported by BioGPS gene expression data to be expressed in 721_B
Rabbit Anti-THRB Polyclonal Antibody – Cat# MBS3203847

Western Blot (WB) of anti-THRB antibody

WB Suggested Anti-THRB Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: MCF7 cell lysate
Rabbit Anti-THRB Polyclonal Antibody, Western Blot (WB) – Cat# MBS3203847

Other Notes

Small volumes of anti-THRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for THRB purchase

MBS3203847 is an antibody targeting THRB. Also known as THRB antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for THRB. It may not necessarily be applicable to this product.

NCBI GI #
40806162
NCBI GeneID
7068
NCBI Accession #
NP_000452
UniProt Primary Accession #
P10828
UniProt Related Accession #
P10828
GenBank Nucleotide #
NM_000461
NCBI Official Full Name
thyroid hormone receptor beta isoform a
NCBI Official Synonym Full Names
thyroid hormone receptor beta
NCBI Official Symbol
THRB
NCBI Official Synonym Symbols
GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; C-ERBA-2; C-ERBA-BETA
UniProt Protein Name
Thyroid hormone receptor beta
UniProt Synonym Protein Names
Nuclear receptor subfamily 1 group A member 2; c-erbA-2; c-erbA-beta
Protein Family
Homoserine kinase
UniProt Gene Name
THRB
UniProt Synonym Gene Names
ERBA2; NR1A2; THR1
UniProt Entry Name
THB_HUMAN
NCBI Protein Information
thyroid hormone receptor beta

NCBI Summary for THRB

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for THRB

TR-beta1: nuclear hormone receptor and transcription factor. High affinity receptor for triiodothyronine. Homolog of the viral oncogene erbB. Two splice variant isoforms have been described.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 3p24.2

Cellular Component: nucleoplasm; nuclear chromatin; nucleus

Molecular Function: protein binding; enzyme binding; DNA binding; zinc ion binding; chromatin DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity; transcription corepressor activity

Biological Process: negative regulation of female receptivity; transcription initiation from RNA polymerase II promoter; organ morphogenesis; female courtship behavior; sensory perception of sound; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; regulation of heart contraction

Disease: Thyroid Hormone Resistance, Selective Pituitary; Thyroid Hormone Resistance, Generalized, Autosomal Dominant; Thyroid Hormone Resistance, Generalized, Autosomal Recessive
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Research Articles on THRB

1. Age-related decrease of THRB expression in peripheral blood mononuclear cells of elderly and long-lived humans might be, in part, a result of the increased methylation of its promoter, but is unrelated to the activity of the miRNAs

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-THRB antibody

 Reference Product  PubMed Publications
 TP53 antibody  >3 publications with THRB and TP53
 RXRA antibody  >2 publications with THRB and RXRA
 NCOR1 antibody  >2 publications with THRB and NCOR1
 RXRG antibody  >1 publications with THRB and RXRG
 ESR1 antibody  >1 publications with THRB and ESR1

Pathways associated with anti-THRB antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram

Diseases associated with anti-THRB antibody

 Disease Name  Pubmed Publications
 Thyroid Diseases Antibodies  >39 publications with THRB and Thyroid Diseases
 Thyroid Hormone Resistance Syndrome Antibodies  >21 publications with THRB and Thyroid Hormone Resistance Syndrome
 Hypothyroidism Antibodies  >17 publications with THRB and Hypothyroidism
 Nervous System Diseases Antibodies  >14 publications with THRB and Nervous System Diseases
 Goiter Antibodies  >7 publications with THRB and Goiter
 Hyperplasia Antibodies  >5 publications with THRB and Hyperplasia
 Prostatic Diseases Antibodies  >5 publications with THRB and Prostatic Diseases
 Brain Diseases Antibodies  >5 publications with THRB and Brain Diseases
 Genital Diseases, Male Antibodies  >5 publications with THRB and Genital Diseases, Male
 Kidney Diseases Antibodies  >5 publications with THRB and Kidney Diseases
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