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SOX2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3203972

This is a rabbit polyclonal antibody against SOX2. It was validated on Western Blot using a cell lysate as a positive control.Target Description: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
SOX2, Polyclonal Antibody
Full Product Name
SOX2 antibody - middle region
Product Gene Name
anti-SOX2 antibody
Product Synonym Gene Name
ANOP3; MCOPS3; MGC2413
Immunogen Sequence
Synthetic peptide located within the following region: AGDLRDMISM YLPGAEVPEP AAPSRLHMSQ HYQSGPVPGT AINGTLPLSH
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
SOX2 peptide (MBS3228938) is used for blocking the activity of SOX2 antibody (MBS3203972)
Molecular Weight
34kDa
OMIM
184429
3D Structure
ModBase 3D Structure for P48431
Homology
Cow: 100%; Dog: 100%; Goat: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 86%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SOX2

Product Categories/Family for anti-SOX2 antibody

Polyclonal; Transcription Factor; Transcription Regulation; Transcription Regulation; Developmental Biology; Neuroscience; Stem Cells; Immunohistochemistry; Transcription Factors
Applications Tested/Suitable for anti-SOX2 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-SOX2 antibody

Sample Type :
Human brain stem cells
Primary Antibody Dilution :
1:500
Secondary Antibody :
Goat anti-rabbit Alexa-Fluor 594
Secondary Antibody Dilution :
1:1000
Color/Signal Descriptions :
SOX2: Red DAPI:Blue
Gene Name :
SOX2
Submitted by :
Dr. Yuzhi Chen, University of Arkansas for Medical Science
Rabbit Anti-SOX2 Polyclonal Antibody – Cat# MBS3203972

Western Blot (WB) of anti-SOX2 antibody

Sample Type: Mouse, Rat
Sample Type:2. mouse brain extracts (80ug)
3. rat brain extract(80ug)
Primary Antibody Dilution:2ug/ml
Secondary Antibody: IRDye 800CW goat anti-rabbit from Li-COR Bioscience
Secondary Antibody Dilution:1: 20,000
Image Submitted by: Yuzhi Chen
University of Arkansas for Medical Science
Rabbit Anti-SOX2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3203972

Western Blot (WB) of anti-SOX2 antibody

WB Suggested Anti-SOX2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: HT1080 cell lysate
Rabbit Anti-SOX2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3203972

Western Blot (WB) of anti-SOX2 antibody

WB Suggested Anti-SOX2 antibody Titration: 1 ug/mL
Sample Type: Human Hela
Rabbit Anti-SOX2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3203972

Western Blot (WB) of anti-SOX2 antibody

WB Suggested Anti-SOX2 antibody Titration: 1 ug/mL
Sample Type: Human Hela
Rabbit Anti-SOX2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3203972

Western Blot (WB) of anti-SOX2 antibody

WB Suggested Anti-SOX2 antibody Titration: 1 ug/mL
Sample Type: Human OVCAR-3
Rabbit Anti-SOX2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3203972

Western Blot (WB) of anti-SOX2 antibody

WB Suggested Anti-SOX2 antibody Titration: 1 ug/mL
Sample Type: Human OVCAR-3
Rabbit Anti-SOX2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3203972

Other Notes

Small volumes of anti-SOX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SOX2 purchase

MBS3203972 is an antibody targeting SOX2. Also known as SOX2 antibody - middle region. Reactive in Cow, Dog, Goat, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SOX2. It may not necessarily be applicable to this product.

NCBI GI #
28195386
NCBI GeneID
6657
NCBI Accession #
NP_003097
UniProt Primary Accession #
P48431
UniProt Related Accession #
P48431
GenBank Nucleotide #
NM_003106
NCBI Official Full Name
transcription factor SOX-2
NCBI Official Synonym Full Names
SRY-box 2
NCBI Official Symbol
SOX2
NCBI Official Synonym Symbols
ANOP3; MCOPS3
UniProt Protein Name
Transcription factor SOX-2
UniProt Gene Name
SOX2
UniProt Entry Name
SOX2_HUMAN
NCBI Protein Information
transcription factor SOX-2

NCBI Summary for SOX2

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
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Research Articles on SOX2

1. BRACHYURY and SOX2 synergistically promote cancer stemness in oral cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SOX2 antibody

 Reference Product  PubMed Publications
 NANOG antibody  >1014 publications with SOX2 and NANOG
 POU5F1 antibody  >795 publications with SOX2 and POU5F1
 PAX6 antibody  >151 publications with SOX2 and PAX6
 FGF4 antibody  >61 publications with SOX2 and FGF4
 ATOH1 antibody  >23 publications with SOX2 and ATOH1
 EYA1 antibody  >9 publications with SOX2 and EYA1
 FGF10 antibody  >7 publications with SOX2 and FGF10
 POU2F1 antibody  >5 publications with SOX2 and POU2F1
 SPP1 antibody  >2 publications with SOX2 and SPP1

Pathways associated with anti-SOX2 antibody

 Products by Pathway  Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Wnt Signaling Pathway And Pluripotency antibodies  Wnt Signaling Pathway And Pluripotency Diagram

Diseases associated with anti-SOX2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >554 publications with SOX2 and Neoplasms
 Carcinoma Antibodies  >265 publications with SOX2 and Carcinoma
 Death Antibodies  >110 publications with SOX2 and Death
 Lung Diseases Antibodies  >61 publications with SOX2 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >60 publications with SOX2 and Cell Transformation, Neoplastic
 Carcinoma, Squamous Cell Antibodies  >58 publications with SOX2 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >58 publications with SOX2 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >40 publications with SOX2 and Neoplasm Metastasis
 Small Cell Lung Carcinoma Antibodies  >39 publications with SOX2 and Small Cell Lung Carcinoma
 Anophthalmos Antibodies  >37 publications with SOX2 and Anophthalmos

Organs/Tissues associated with anti-SOX2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >569 publications with SOX2 and Embryonic Tissue
 Brain Antibodies  >509 publications with SOX2 and Brain
 Eye Antibodies  >209 publications with SOX2 and Eye
 Lung Antibodies  >120 publications with SOX2 and Lung
 Testis Antibodies  >86 publications with SOX2 and Testis
 Ear Antibodies  >82 publications with SOX2 and Ear
 Prostate Antibodies  >30 publications with SOX2 and Prostate
 Uncharacterized Tissue Antibodies  >3 publications with SOX2 and Uncharacterized Tissue
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