FMR1 Antibody – Rabbit Polyclonal

Function: Translation repressor. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates translation repression. RNA-binding protein that plays a role in intracellular RNA transport and in the regulation of translation of target mRNAs. Associated with polysomes. Involved in the transport of mRNA from the nucleus to the cytoplasm. Binds strongly to poly(G), binds moderately to poly(U) but shows very little binding to poly(A) or poly(C)

By similarity.

Subunit structure: Homooligomer. Found in a RNP granule complex with IGF2BP1. Directly interacts with SMN and TDRD3. Interacts with the SMN core complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Interacts with FXR1, FXR2, IGF2BP1, NUFIP1, NUFIP2, MCRS1 and RANBP9. Component of the CYFIP1-EIF4E-FMR1 complex which is composed of CYFIP, EIF4E and FMR1. Interacts with CYFIP1 and CYFIP2. The interaction with brain cytoplasmic RNA 1 (BC1) increases binding affinity for the CYFIP1-EIF4E complex in the brain

By similarity.

Subcellular location: Cytoplasm

By similarity. Nucleus › nucleolus

By similarity.

Domain: The tandem Tudor domains preferentially recognize trimethylated histone peptides

By similarity.

Post-translational modification: Phosphorylated on several serine residues

By similarity.

Miscellaneous: RNA-binding activity is inhibited by RANBP9

By similarity.

Sequence similarities: Belongs to the FMR1 family.Contains 2 Agenet-like domains.Contains 2 KH domains.

Sequence caution: The sequence AAB07073.1 differs from that shown. Reason: N-ter sequencing errors.