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SFPQ Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3205326

This is a rabbit polyclonal antibody against SFPQ. It was validated on Western Blot and immunohistochemistryTarget Description: SFPQ is DNA- and RNA binding protein. It is essential pre-mRNA splicing factor required early in spliceosome formation and for… More details

$440 / 0.1 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SFPQ, Polyclonal Antibody
Full Product Name
SFPQ antibody - middle region
Product Gene Name
anti-SFPQ antibody
Product Synonym Gene Name
POMP100; PSF
Immunogen Sequence
Synthetic peptide located within the following region: PVIVEPLEQL DDEDGLPEKL AQKNPMYQKE RETPPRFAQH GTFEYEYSQR
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Protein A purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
SFPQ peptide (MBS3230291) is used for blocking the activity of SFPQ antibody (MBS3205326)
Molecular Weight
78kDa
OMIM
605199
3D Structure
ModBase 3D Structure for P23246
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SFPQ

Product Categories/Family for anti-SFPQ antibody

Polyclonal; RNA Binding Proteins; Transcription Regulation; DNA/RNA/Protein Interactions; Immunohistochemistry; DNA Repair; Transcription Factors
Applications Tested/Suitable for anti-SFPQ antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-SFPQ antibody

Rabbit Anti-SFPQ antibody
Paraffin Embedded Tissue: Human Heart
cell Cellular Data: cardiac cell
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
Rabbit Anti-SFPQ Polyclonal Antibody – Cat# MBS3205326

Immunohistochemistry (IHC) of anti-SFPQ antibody

Rabbit Anti-SFPQ Antibody
Paraffin Embedded Tissue: Human Muscle
Cellular Data: Skeletal muscle cells
Antibody Concentration: 4.0-8.0 ug/ml
Magnification: 400X
Rabbit Anti-SFPQ Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3205326

Western Blot (WB) of anti-SFPQ antibody

WB Suggested Anti-SFPQ Antibody Titration: 5.0ug/ml
Positive Control: Jurkat cell lysateSFPQ is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Rabbit Anti-SFPQ Polyclonal Antibody, Western Blot (WB) – Cat# MBS3205326

Other Notes

Small volumes of anti-SFPQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SFPQ purchase

MBS3205326 is an antibody targeting SFPQ. Also known as SFPQ antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SFPQ. It may not necessarily be applicable to this product.

NCBI GI #
4826998
NCBI GeneID
6421
NCBI Accession #
NP_005057
UniProt Primary Accession #
P23246
UniProt Related Accession #
P23246
GenBank Nucleotide #
NM_005066
NCBI Official Full Name
splicing factor, proline- and glutamine-rich
NCBI Official Synonym Full Names
splicing factor proline and glutamine rich
NCBI Official Symbol
SFPQ
NCBI Official Synonym Symbols
PSF; POMP100; PPP1R140
UniProt Protein Name
Splicing factor, proline- and glutamine-rich
UniProt Synonym Protein Names
100 kDa DNA-pairing protein; hPOMp100; DNA-binding p52/p100 complex, 100 kDa subunit; Polypyrimidine tract-binding protein-associated-splicing factor; PSF; PTB-associated-splicing factor
Protein Family
Splicing factor
UniProt Gene Name
SFPQ
UniProt Synonym Gene Names
PSF; hPOMp100; PSF; PTB-associated-splicing factor
UniProt Entry Name
SFPQ_HUMAN
NCBI Protein Information
splicing factor, proline- and glutamine-rich

UniProt Comments for SFPQ

PSF: a proline-and glutamine-rich splicing factor. Essential pre-mRNA splicing factor required early in spliceosome formation. Seems to also bind DNA. The active complex is a heterotetramer of two 52 kDa and two 100 kDa subunits. Reported to be a PKC-alpha-binding protein in the cell nucleus. Two alternatively spliced isoforms have been described.

Protein type: RNA splicing; RNA-binding; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; nuclear matrix; cytoplasm; nucleus; paraspeckles; chromatin

Molecular Function: protein binding; histone deacetylase binding; nucleotide binding

Biological Process: alternative nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; RNA splicing; rhythmic process; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; DNA repair; mRNA processing; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; DNA recombination
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Research Articles on SFPQ

1. SFPQ dislocation was found enhanced with tau co-transfection and tau co-transfection further resulted in extended DNA disorganization in N2a cells. Overall, our results indicate that dysregulation and dislocation of SFPQ and subsequent DNA disorganization might be a novel pathway in the progression of Alzheimer's disease and frontotemporal dementia.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SFPQ antibody

 Reference Product  PubMed Publications
 NONO antibody  >16 publications with SFPQ and NONO
 PSPC1 antibody  >7 publications with SFPQ and PSPC1
 HDAC1 antibody  >1 publications with SFPQ and HDAC1

Pathways associated with anti-SFPQ antibody

 Products by Pathway  Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with anti-SFPQ antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with SFPQ and Nervous System Diseases
 Inflammation Antibodies  >3 publications with SFPQ and Inflammation
 Brain Diseases Antibodies  >2 publications with SFPQ and Brain Diseases
 Adenocarcinoma Antibodies  >2 publications with SFPQ and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >1 publications with SFPQ and Cell Transformation, Neoplastic
 Infertility, Female Antibodies  >1 publications with SFPQ and Infertility, Female
 Disease Models, Animal Antibodies  >1 publications with SFPQ and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with SFPQ and Lung Neoplasms
 Kidney Diseases Antibodies  >1 publications with SFPQ and Kidney Diseases
 Learning Disorders Antibodies  >1 publications with SFPQ and Learning Disorders

Organs/Tissues associated with anti-SFPQ antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with SFPQ and Brain
 Blood Antibodies  >5 publications with SFPQ and Blood
 Nerve Antibodies  >4 publications with SFPQ and Nerve
 Kidney Antibodies  >3 publications with SFPQ and Kidney
 Prostate Antibodies  >1 publications with SFPQ and Prostate
 Heart Antibodies  >1 publications with SFPQ and Heart
 Lymph Node Antibodies  >1 publications with SFPQ and Lymph Node
 Eye Antibodies  >1 publications with SFPQ and Eye
 Testis Antibodies  >1 publications with SFPQ and Testis
 Lymph Antibodies  >1 publications with SFPQ and Lymph
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