Rabbit Anti-DROSHA Polyclonal Antibody – Cat# MBS3205442

WB Suggested Anti-RNASEN Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human Spleen

DROSHA Antibody – Rabbit Polyclonal

Name: DROSHA Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3205442
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3205442

This is a rabbit polyclonal antibody against RNASEN. It was validated on Western Blot using a cell lysate as a positive control.Target Description: RNASEN is a ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RNASEN (DROSHA), Polyclonal Antibody

Full Product Name

RNASEN antibody - middle region

Product Gene Name

anti-DROSHA antibody

Product Synonym Gene Name

DROSHA; ETOHI2; HSA242976; RANSE3L; RN3; RNASE3L; RNASEN

Immunogen Sequence

Synthetic peptide located within the following region: AAMDALEKYN FPQMAHQKRF IERKYRQELK EMRWEREHQE REPDETEDIK

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

RNASEN peptide (MBS3230408) is used for blocking the activity of RNASEN antibody (MBS3205442)

Molecular Weight

159kDa

OMIM

AF189011 mRNA

3D Structure

ModBase 3D Structure for Q9NRR4

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human RNASEN

Product Categories/Family for anti-DROSHA antibody

Polyclonal; RNA Binding Proteins; Chromatin & Nuclear Signaling; Signal Transduction; Stem Cells

Applications Tested/Suitable for anti-DROSHA antibody

Western Blot (WB)

Other Notes

Small volumes of anti-DROSHA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DROSHA purchase

MBS3205442 is an antibody targeting DROSHA. Also known as RNASEN antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DROSHA. It may not necessarily be applicable to this product.

NCBI GI #

155030234

NCBI GeneID

29102

NCBI Accession #

NP_037367

UniProt Primary Accession #

Q9NRR4

UniProt Related Accession #

Q9NRR4

GenBank Nucleotide #

NM_013235

NCBI Official Full Name

ribonuclease 3 isoform 1

NCBI Official Synonym Full Names

drosha ribonuclease III

NCBI Official Symbol

DROSHA

NCBI Official Synonym Symbols

RN3; ETOHI2; RNASEN; RANSE3L; RNASE3L; HSA242976

UniProt Protein Name

Ribonuclease 3

UniProt Synonym Protein Names

Protein Drosha

UniProt Gene Name

DROSHA

UniProt Synonym Gene Names

RN3; RNASE3L; RNASEN; RNase III

NCBI Protein Information

ribonuclease 3

NCBI Summary for DROSHA

This gene encodes a ribonuclease (RNase) III double-stranded RNA-specific ribonuclease and subunit of the microprocessor protein complex, which catalyzes the initial processing step of microRNA (miRNA) synthesis. The encoded protein cleaves the stem loop structure from the primary microRNA (pri-miRNA) in the nucleus, yielding the precursor miRNA (pre-miRNA), which is then exported to the cytoplasm for further processing. In a human cell line lacking a functional copy of this gene, canonical miRNA synthesis is reduced. Somatic mutations in this gene have been observed in human patients with kidney cancer. [provided by RefSeq, Sep 2016]

UniProt Comments for DROSHA

Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.

Research Articles on DROSHA

1. analysis of the recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DROSHA antibody

Reference Product	PubMed Publications
DGCR8 antibody	>66 publications with DROSHA and DGCR8
SP1 antibody	>2 publications with DROSHA and SP1

Pathways associated with anti-DROSHA antibody

Products by Pathway	Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
MicroRNA (miRNA) Biogenesis Pathway antibodies	MicroRNA (miRNA) Biogenesis Pathway Diagram
Regulatory RNA Pathways antibodies	Regulatory RNA Pathways Diagram
Ribosome Biogenesis In Eukaryotes Pathway antibodies	Ribosome Biogenesis In Eukaryotes Pathway Diagram
Ribosome Biogenesis In Eukaryotes Pathway antibodies	Ribosome Biogenesis In Eukaryotes Pathway Diagram

Diseases associated with anti-DROSHA antibody

Disease Name	Pubmed Publications
Adenocarcinoma Antibodies	>22 publications with DROSHA and Adenocarcinoma
Uterine Neoplasms Antibodies	>9 publications with DROSHA and Uterine Neoplasms
Thrombosis Antibodies	>4 publications with DROSHA and Thrombosis
Infertility, Male Antibodies	>3 publications with DROSHA and Infertility, Male
Infertility, Female Antibodies	>3 publications with DROSHA and Infertility, Female
Cholestasis Antibodies	>2 publications with DROSHA and Cholestasis
Fatty Liver Antibodies	>1 publications with DROSHA and Fatty Liver
Thrombophilia Antibodies	>1 publications with DROSHA and Thrombophilia
Arteriosclerosis Antibodies	>1 publications with DROSHA and Arteriosclerosis

Organs/Tissues associated with anti-DROSHA antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>122 publications with DROSHA and Blood
Liver Antibodies	>56 publications with DROSHA and Liver
Muscle Antibodies	>50 publications with DROSHA and Muscle
Kidney Antibodies	>47 publications with DROSHA and Kidney
Brain Antibodies	>47 publications with DROSHA and Brain
Heart Antibodies	>40 publications with DROSHA and Heart
Vascular Antibodies	>40 publications with DROSHA and Vascular
Embryonic Tissue Antibodies	>34 publications with DROSHA and Embryonic Tissue
Lung Antibodies	>30 publications with DROSHA and Lung
Ovary Antibodies	>20 publications with DROSHA and Ovary