Rabbit Anti-POLDIP3 Polyclonal Antibody – Cat# MBS3205618

Human Skin

POLDIP3 Antibody – Rabbit Polyclonal

Name: POLDIP3 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3205618
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3205618

This is a rabbit polyclonal antibody against POLDIP3. It was validated on Western Blot using a cell lysate as a positive control.Target Description: POLDIP3 is a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

POLDIP3, Polyclonal Antibody

Full Product Name

POLDIP3 antibody - C-terminal region

Product Gene Name

anti-POLDIP3 antibody

Product Synonym Gene Name

KIAA1649; PDIP46; SKAR

Immunogen Sequence

Synthetic peptide located within the following region: DAITAYKKYN NRCLDGQPMK CNLHMNGNVI TSDQPILLRL SDSPSMKKES

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

POLDIP3 peptide (MBS3230581) is used for blocking the activity of POLDIP3 antibody (MBS3205618)

Molecular Weight

46kDa

OMIM

611520

3D Structure

ModBase 3D Structure for Q9BY77

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human POLDIP3

Product Categories/Family for anti-POLDIP3 antibody

Polyclonal; Signal Proteins; Lymphocyte Signaling; Membrane Protein; Developmental Biology; Immunohistochemistry; Receptors

Applications Tested/Suitable for anti-POLDIP3 antibody

Immunohistochemistry (IHC), Western Blot (WB)

Other Notes

Small volumes of anti-POLDIP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POLDIP3 purchase

MBS3205618 is an antibody targeting POLDIP3. Also known as POLDIP3 antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for POLDIP3. It may not necessarily be applicable to this product.

NCBI GI #

29837655

NCBI GeneID

84271

NCBI Accession #

NP_115687

UniProt Primary Accession #

Q9BY77

UniProt Related Accession #

Q9BY77

GenBank Nucleotide #

NM_032311

NCBI Official Full Name

polymerase delta-interacting protein 3 isoform 1

NCBI Official Synonym Full Names

DNA polymerase delta interacting protein 3

NCBI Official Symbol

POLDIP3

NCBI Official Synonym Symbols

SKAR; PDIP3; PDIP46

UniProt Protein Name

Polymerase delta-interacting protein 3

UniProt Synonym Protein Names

46 kDa DNA polymerase delta interaction protein; p46; S6K1 Aly/REF-like target

Protein Family

Polymerase delta-interacting protein

UniProt Gene Name

POLDIP3

UniProt Synonym Gene Names

KIAA1649; PDIP46; p46; SKAR

UniProt Entry Name

PDIP3_HUMAN

NCBI Protein Information

polymerase delta-interacting protein 3

NCBI Summary for POLDIP3

This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for POLDIP3

SKAR: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nuclear speck

Molecular Function: protein binding; nucleotide binding

Biological Process: poly(A)+ mRNA export from nucleus; positive regulation of translation

Research Articles on POLDIP3

1. Altered expression of PDIP46 or its mutation may affect Pol delta functions in vivo, and thereby be a nexus for altered genomic stability.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-POLDIP3 antibody

Products by Pathway	Pathway Diagram
MTOR Signaling Pathway antibodies	MTOR Signaling Pathway Diagram

Diseases associated with anti-POLDIP3 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2 publications with POLDIP3 and Nervous System Diseases
Death Antibodies	>1 publications with POLDIP3 and Death
Inflammation Antibodies	>1 publications with POLDIP3 and Inflammation
Kidney Diseases Antibodies	>1 publications with POLDIP3 and Kidney Diseases

Organs/Tissues associated with anti-POLDIP3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with POLDIP3 and Brain
Blood Antibodies	>2 publications with POLDIP3 and Blood
Vascular Antibodies	>1 publications with POLDIP3 and Vascular
Kidney Antibodies	>1 publications with POLDIP3 and Kidney
Lung Antibodies	>1 publications with POLDIP3 and Lung