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RHOD Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3206364

This is a rabbit polyclonal antibody against RHOD. It was validated on Western Blot using a cell lysate as a positive control.Target Description: Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They… More details

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Product Overview

Online Datasheet in PDF
Product Name
RHOD, Polyclonal Antibody
Full Product Name
RHOD antibody - C-terminal region
Product Gene Name
anti-RHOD antibody
Product Synonym Gene Name
ARHD; RHOHP1; RHOM; Rho
Immunogen Sequence
Synthetic peptide located within the following region: NGLEPVTYHR GQEMARSVGA VAYLECSARL HDNVHAVFQE AAEVALSSRG
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
RHOD peptide (MBS3231330) is used for blocking the activity of RHOD antibody (MBS3206364)
Molecular Weight
23kDa
OMIM
605781
3D Structure
ModBase 3D Structure for O00212
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 82%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human RHOD

Product Categories/Family for anti-RHOD antibody

Polyclonal; Lymphocyte Signaling; Membrane & Traffic; Immunohistochemistry; Axon Guidance
Applications Tested/Suitable for anti-RHOD antibody
Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-RHOD antibody

RHOD antibody - C-terminal region

Formalin Fixed Paraffin Embedded Tissue: Human Bronchial Epithelial Tissue

Observed Staining: Cytoplasm and membrane of bronchial epithelial tissue

Primary Antibody Concentration: 1:600

Secondary Antibody: Donkey anti-Rabbit-Cy3

Secondary Antibody Concentration: 1:200

Magnification: 20X

Exposure Time: 0.5 - 2.0 sec
Rabbit Anti-RHOD Polyclonal Antibody – Cat# MBS3206364

Immunohistochemistry (IHC) of anti-RHOD antibody

RHOD antibody - C-terminal region

Formalin Fixed Paraffin Embedded Tissue: Human Liver Tissue

Observed Staining: Cytoplasm in sinusoids of liver

Primary Antibody Concentration: 1:100

Other Working Concentrations: 1/600

Secondary Antibody: Donkey anti-Rabbit-Cy3

Secondary Antibody Concentration: 1:200

Magnification: 20X

Exposure Time: 0.5 - 2.0 sec
Rabbit Anti-RHOD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3206364

Immunohistochemistry (IHC) of anti-RHOD antibody

Tonsil
Rabbit Anti-RHOD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3206364

Western Blot (WB) of anti-RHOD antibody

WB Suggested Anti-RHOD Antibody Titration: 0.2-1 ug/ml
Positive Control: Transfected 293T
Rabbit Anti-RHOD Polyclonal Antibody, Western Blot (WB) – Cat# MBS3206364

Other Notes

Small volumes of anti-RHOD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RHOD purchase

MBS3206364 is an antibody targeting RHOD. Also known as RHOD antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RHOD. It may not necessarily be applicable to this product.

NCBI GI #
7656900
NCBI GeneID
29984
NCBI Accession #
NP_055393
UniProt Primary Accession #
O00212
UniProt Related Accession #
O00212
GenBank Nucleotide #
NM_014578
NCBI Official Full Name
rho-related GTP-binding protein RhoD isoform 1
NCBI Official Synonym Full Names
ras homolog family member D
NCBI Official Symbol
RHOD
NCBI Official Synonym Symbols
Rho; ARHD; RHOM; RHOHP1
UniProt Protein Name
Rho-related GTP-binding protein RhoD
UniProt Synonym Protein Names
Rho-related protein HP1
Protein Family
Rho-related GTP-binding protein
UniProt Gene Name
RHOD
UniProt Synonym Gene Names
ARHD; RhoHP1
UniProt Entry Name
RHOD_HUMAN
NCBI Protein Information
rho-related GTP-binding protein RhoD

NCBI Summary for RHOD

Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
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UniProt Comments for RHOD

RHOD: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton. Belongs to the small GTPase superfamily. Rho family.

Protein type: G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rho; G protein

Chromosomal Location of Human Ortholog: 11q14.3

Cellular Component: early endosome; plasma membrane; cytosol

Molecular Function: GTPase activity; GTP binding; protein kinase binding

Biological Process: lamellipodium biogenesis; focal adhesion formation; actin filament bundle formation; regulation of small GTPase mediated signal transduction; positive regulation of cell adhesion; metabolic process; small GTPase mediated signal transduction; regulation of focal adhesion formation; Rho protein signal transduction; protein targeting; positive regulation of cell migration
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Research Articles on RHOD

1. The GTPase deficient atypical Rho GTPases, which have a stalled GTPase activity, RhoD has an elevated intrinsic GDP/GTP exchange activity, rendering the protein constitutively active.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RHOD antibody

 Reference Product  PubMed Publications
 DIAPH2 antibody  >2 publications with RHOD and DIAPH2
 PLXNA1 antibody  >1 publications with RHOD and PLXNA1

Pathways associated with anti-RHOD antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram

Diseases associated with anti-RHOD antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >11 publications with RHOD and Necrosis
 Inflammation Antibodies  >7 publications with RHOD and Inflammation
 Carcinoma Antibodies  >5 publications with RHOD and Carcinoma
 Blood Coagulation Disorders Antibodies  >3 publications with RHOD and Blood Coagulation Disorders
 Liver Diseases Antibodies  >3 publications with RHOD and Liver Diseases
 Neoplasm Metastasis Antibodies  >3 publications with RHOD and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >3 publications with RHOD and Adenocarcinoma
 Hemorrhage Antibodies  >3 publications with RHOD and Hemorrhage
 Kidney Neoplasms Antibodies  >2 publications with RHOD and Kidney Neoplasms
 Fatty Liver Antibodies  >2 publications with RHOD and Fatty Liver

Organs/Tissues associated with anti-RHOD antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >122 publications with RHOD and Muscle
 Heart Antibodies  >103 publications with RHOD and Heart
 Eye Antibodies  >22 publications with RHOD and Eye
 Kidney Antibodies  >13 publications with RHOD and Kidney
 Liver Antibodies  >9 publications with RHOD and Liver
 Pancreas Antibodies  >8 publications with RHOD and Pancreas
 Lung Antibodies  >7 publications with RHOD and Lung
 Embryonic Tissue Antibodies  >6 publications with RHOD and Embryonic Tissue
 Bone Antibodies  >6 publications with RHOD and Bone
 Intestine Antibodies  >6 publications with RHOD and Intestine
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