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GZMH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3206509

This is a rabbit polyclonal antibody against GZMH. It was validated on Western Blot and immunohistochemistryTarget Description: This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. More details

$440 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
GZMH, Polyclonal Antibody
Full Product Name
GZMH antibody - N-terminal region
Product Gene Name
Product Synonym Gene Name
CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2
Immunogen Sequence
Synthetic peptide located within the following region: MQPFLLLLAF LLTPGAGTEE IIGGHEAKPH SRPYMAFVQF LQEKSRKRCG
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Horse, Human, Mouse, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Protein A purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
GZMH peptide (MBS3231473) is used for blocking the activity of GZMH antibody (MBS3206509)
Molecular Weight
27kDa
OMIM
116831
3D Structure
ModBase 3D Structure for P20718
Homology
Horse: 85%; Human: 100%; Mouse: 91%; Rat: 92%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human GZMH
Applications Tested/Suitable for anti-GZMH antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-GZMH antibody

Human kidney
Rabbit Anti-GZMH Polyclonal Antibody – Cat# MBS3206509

Other Notes

Small volumes of anti-GZMH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GZMH purchase

MBS3206509 is an antibody targeting GZMH. Also known as GZMH antibody - N-terminal region. Reactive in Horse, Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GZMH. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
granzyme H isoform 1 preproprotein
NCBI Official Synonym Full Names
granzyme H
NCBI Official Symbol
GZMH
NCBI Official Synonym Symbols
CCP-X; CGL-2; CSP-C; CTLA1; CTSGL2
UniProt Protein Name
Granzyme H
UniProt Synonym Protein Names
CCP-X; Cathepsin G-like 2; CTSGL2; Cytotoxic T-lymphocyte proteinase; Cytotoxic serine protease C
Protein Family
UniProt Gene Name
GZMH
UniProt Synonym Gene Names
CGL2; CTSGL2; CTSGL2; CSP-C
UniProt Entry Name
GRAH_HUMAN
NCBI Protein Information
granzyme H

NCBI Summary for GZMH

This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015]
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UniProt Comments for GZMH

GZMF: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: EC 3.4.21.-; Protease

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: membrane; intracellular membrane-bound organelle; cytoplasm

Molecular Function: serine-type endopeptidase activity

Biological Process: apoptosis; cytolysis; immune response; protein processing; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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