ITGB1BP3 (NMRK2) Antibody – Rabbit Polyclonal

ITGB1BP3: an enzyme that catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside to form nicotinamide mononucleotide and nicotinic acid mononucleotide. Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta. May play a role in the regulation of terminal myogenesis. Two alternatively spliced human isoforms have been described.

Protein type: EC 2.7.1.22; Cell adhesion; EC 2.7.1.173; Cell development/differentiation; Kinase, other

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: intracellular

Molecular Function: protein binding; ribosylnicotinamide kinase activity; metal ion binding; ATP binding

Biological Process: NAD biosynthetic process; negative regulation of myoblast differentiation; phosphorylation