PLPP1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

PPAP2A: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma. Belongs to the PA-phosphatase related phosphoesterase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Lipid Metabolism - sphingolipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Membrane protein, multi-pass; Lipid Metabolism - glycerolipid; Phosphatase (non-protein); EC 3.1.3.4

Chromosomal Location of Human Ortholog: 5q11

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: phosphatidate phosphatase activity

Biological Process: steroid hormone receptor signaling pathway; negative regulation of cell proliferation; regulation of lipid metabolic process; sphingolipid metabolic process; sphingolipid biosynthetic process; germ cell migration; protein kinase C activation; androgen receptor signaling pathway; lipid metabolic process; protein amino acid dephosphorylation; phospholipid dephosphorylation