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TJP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3206626

This is a rabbit polyclonal antibody against TJP2. It was validated on Western Blot using a cell lysate as a positive control.Target Description: Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that… More details

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Product Overview

Online Datasheet in PDF
Product Name
TJP2, Polyclonal Antibody
Full Product Name
TJP2 antibody - C-terminal region
Product Gene Name
anti-TJP2 antibody
Product Synonym Gene Name
MGC26306; X104; ZO-2; ZO2; DFNA51; DUP9q21.11; C9DUPq21.11
Immunogen Sequence
Synthetic peptide located within the following region: EPQKAPSRPY QDTRGSYGSD AEEEEYRQQL SEHSKRGYYG QSARYRDTEL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
TJP2 peptide (MBS3231590) is used for blocking the activity of TJP2 antibody (MBS3206626)
Molecular Weight
118kDa
3D Structure
ModBase 3D Structure for A2A3H9
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 82%
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human TJP2

Product Categories/Family for anti-TJP2 antibody

Polyclonal; Membrane & Traffic
Applications Tested/Suitable for anti-TJP2 antibody
Western Blot (WB)

Western Blot (WB) of anti-TJP2 antibody

WB Suggested Anti-TJP2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysate
Rabbit Anti-TJP2 Polyclonal Antibody – Cat# MBS3206626

Other Notes

Small volumes of anti-TJP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TJP2 purchase

MBS3206626 is an antibody targeting TJP2. Also known as TJP2 antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TJP2. It may not necessarily be applicable to this product.

NCBI GI #
42518065
NCBI GeneID
9414
NCBI Accession #
NP_963923
UniProt Primary Accession #
A2A3H9
UniProt Related Accession #
Q9UDY2
GenBank Nucleotide #
NM_201629
NCBI Official Full Name
tight junction protein ZO-2 isoform 2
NCBI Official Synonym Full Names
tight junction protein 2
NCBI Official Symbol
TJP2
NCBI Official Synonym Symbols
ZO2; X104; PFIC4; DFNA51; DUP9q21.11; C9DUPq21.11
Protein Family
Tight junction protein
NCBI Protein Information
tight junction protein ZO-2

NCBI Summary for TJP2

This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
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Research Articles on TJP2

1. Biochemistry and microscopy approaches in T cells confirmed SNX27/ZO-2 PDZ-dependent interaction, and demonstrated its role controlling the dynamic localization of ZO-2 at the IS

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TJP2 antibody

 Reference Product  PubMed Publications
 TJP1 antibody  >87 publications with TJP2 and TJP1
 OCLN antibody  >48 publications with TJP2 and OCLN
 CLDN1 antibody  >21 publications with TJP2 and CLDN1
 CLDN2 antibody  >6 publications with TJP2 and CLDN2
 CGN antibody  >2 publications with TJP2 and CGN
 GJA1 antibody  >1 publications with TJP2 and GJA1
 WWTR1 antibody  >1 publications with TJP2 and WWTR1
 SAFB antibody  >1 publications with TJP2 and SAFB

Pathways associated with anti-TJP2 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cell Adhesion Proteins Pathway antibodies  Apoptotic Cleavage Of Cell Adhesion Proteins Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hippo Pathway antibodies  Signaling By Hippo Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
 Vibrio Cholerae Infection Pathway antibodies  Vibrio Cholerae Infection Pathway Diagram

Diseases associated with anti-TJP2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with TJP2 and Neoplasms
 Nervous System Diseases Antibodies  >10 publications with TJP2 and Nervous System Diseases
 Inflammation Antibodies  >8 publications with TJP2 and Inflammation
 Brain Diseases Antibodies  >7 publications with TJP2 and Brain Diseases
 Liver Diseases Antibodies  >5 publications with TJP2 and Liver Diseases
 Necrosis Antibodies  >5 publications with TJP2 and Necrosis
 Edema Antibodies  >4 publications with TJP2 and Edema
 Disease Models, Animal Antibodies  >4 publications with TJP2 and Disease Models, Animal
 Hearing Loss Antibodies  >4 publications with TJP2 and Hearing Loss
 Breast Neoplasms Antibodies  >3 publications with TJP2 and Breast Neoplasms

Organs/Tissues associated with anti-TJP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >14 publications with TJP2 and Intestine
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