Rabbit Anti-HERC4 Polyclonal Antibody – Cat# MBS3206653

WB Suggested Anti-HERC4 Antibody
Titration: 1.0 ug/ml
Positive Control: Fetal Liver

HERC4 Antibody – Rabbit Polyclonal

Name: HERC4 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3206653
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3206653

This is a rabbit polyclonal antibody against HERC4. It was validated on Western BlotTarget Description: HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HERC4, Polyclonal Antibody

Full Product Name

HERC4 antibody - middle region

Product Gene Name

anti-HERC4 antibody

Product Synonym Gene Name

DKFZp564G092; KIAA1593

Immunogen Sequence

Synthetic peptide located within the following region: VGCGLRHTVF VLDDGTVYTC GCNDLGQLGH EKSRKKPEIL KVCQISRLYR

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

HERC4 peptide (MBS3231617) is used for blocking the activity of HERC4 antibody (MBS3206653)

Molecular Weight

13kDa

OMIM

AY221963 mRNA

3D Structure

ModBase 3D Structure for Q5GLZ8

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human HERC4

Product Categories/Family for anti-HERC4 antibody

Polyclonal; Cardiovascular; Developmental Biology; Cell Differentiation

Applications Tested/Suitable for anti-HERC4 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-HERC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HERC4 purchase

MBS3206653 is an antibody targeting HERC4. Also known as HERC4 antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HERC4. It may not necessarily be applicable to this product.

NCBI GI #

63025218

NCBI GeneID

26091

NCBI Accession #

NP_001017972

UniProt Primary Accession #

Q5GLZ8

UniProt Related Accession #

Q5GLZ8

GenBank Nucleotide #

NM_001017972

NCBI Official Synonym Full Names

HECT and RLD domain containing E3 ubiquitin protein ligase 4

NCBI Official Symbol

HERC4

UniProt Protein Name

Probable E3 ubiquitin-protein ligase HERC4

UniProt Synonym Protein Names

HECT domain and RCC1-like domain-containing protein 4; HECT-type E3 ubiquitin transferase HERC4

Protein Family

Probable E3 ubiquitin-protein ligase

UniProt Gene Name

HERC4

UniProt Synonym Gene Names

KIAA1593

NCBI Protein Information

probable E3 ubiquitin-protein ligase HERC4

NCBI Summary for HERC4

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

UniProt Comments for HERC4

HERC4: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: cytoplasm; cytosol; fibrillar center

Biological Process: cell differentiation; protein ubiquitination; spermatogenesis

Research Articles on HERC4

1. HERC4 has an effect on the occurrence and development of hepatoma carcinoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.