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PTPRH Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3206914

This is a rabbit polyclonal antibody against PTPRH. It was validated on Western Blot using a cell lysate as a positive control.Target Description: PTPRH is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules… More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PTPRH, Polyclonal Antibody
Full Product Name
PTPRH antibody - middle region
Product Gene Name
Product Synonym Gene Name
FLJ39938; MGC133058; MGC133059; SAP-1; SAP1
Immunogen Sequence
Synthetic peptide located within the following region: QTKNSVMLWW KAPGDPHSQL YVYWVQWASK GHPRRGQDPQ ANWVNQTSRT
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
PTPRH peptide (MBS3231878) is used for blocking the activity of PTPRH antibody (MBS3206914)
Molecular Weight
120kDa
OMIM
602510
3D Structure
ModBase 3D Structure for Q9HD43
Homology
Human: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human PTPRH
Applications Tested/Suitable for anti-PTPRH antibody
Western Blot (WB)

Western Blot (WB) of anti-PTPRH antibody

WB Suggested Anti-PTPRH Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: MCF7 cell lysate
Rabbit Anti-PTPRH Polyclonal Antibody – Cat# MBS3206914

Other Notes

Small volumes of anti-PTPRH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTPRH purchase

MBS3206914 is an antibody targeting PTPRH. Also known as PTPRH antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPRH. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
receptor-type tyrosine-protein phosphatase H isoform 1
NCBI Official Synonym Full Names
protein tyrosine phosphatase receptor type H
NCBI Official Symbol
PTPRH
NCBI Official Synonym Symbols
SAP1; R-PTP-H
UniProt Protein Name
Receptor-type tyrosine-protein phosphatase H
UniProt Synonym Protein Names
Stomach cancer-associated protein tyrosine phosphatase 1; SAP-1; Transmembrane-type protein-tyrosine phosphatase type H
UniProt Gene Name
PTPRH
UniProt Synonym Gene Names
SAP1; R-PTP-H; SAP-1
UniProt Entry Name
PTPRH_HUMAN
NCBI Protein Information
receptor-type tyrosine-protein phosphatase H

NCBI Summary for PTPRH

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
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UniProt Comments for PTPRH

PTPRH: May contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion- associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of p130cas, focal adhesion kinase and c-Src. Reduces migratory activity of Jurkat cells. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 3.1.3.48; Receptor protein phosphatase, tyrosine

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane; cytoplasm

Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity

Biological Process: apoptosis; protein amino acid dephosphorylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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