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GCNT3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3206915

This is a rabbit polyclonal antibody against GCNT3. It was validated on Western Blot and immunohistochemistryTarget Description: This enzyme catalyzes O-glycan branch synthesis of the core 2 and core 4 type in mucins and controls expression of core 2 branched… More details

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Product Overview

Online Datasheet in PDF
Product Name
GCNT3, Polyclonal Antibody
Full Product Name
GCNT3 antibody - C-terminal region
Product Gene Name
anti-GCNT3 antibody
Product Synonym Gene Name
C2/4GnT; C2GnT-M; C2GnT2; GnT-M; GNTM; C24GNT; C2GNT2; C2GNTM
Immunogen Sequence
Synthetic peptide located within the following region: AICVYGAGDL NWMLQNHHLL ANKFDPKVDD NALQCLEEYL RYKAIYGTEL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Tested Species Reactivity: Human
Predicted Species Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Yeast
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Protein A purified
Concentration
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml (lot specific)
Preparation and Storage
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
GCNT3 peptide (MBS3231879) is used for blocking the activity of GCNT3 antibody (MBS3206915)
Molecular Weight
51kDa
OMIM
606836
3D Structure
ModBase 3D Structure for O95395
Protein Size (# AA)
438 amino acids
Protein Interactions
DHRSX; RBM18; SNUPN; CASK;
Immunogen
The immunogen is a synthetic peptide directed towards the C terminal region of human GCNT3
Replacement Item
This antibody may replace item sc-112929, HPA011154
Predicted Homology Based on Immunogen Sequence
Cow: 93%; Dog: 100%; Guinea Pig: 91%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 93%; Rat: 93%; Sheep: 93%; Yeast: 89%

Product Categories/Family for anti-GCNT3 antibody

Polyclonal; Signal Proteins; Lymphocyte Signaling; Membrane Protein; Drugs and Drug Metabolism; Developmental Biology; Immunohistochemistry; Receptors; Glycosylation
Applications Tested/Suitable for anti-GCNT3 antibody
Immunohistochemistry (IHC), Western Blot (WB)

Immunohistochemistry (IHC) of anti-GCNT3 antibody

Human kidney
Rabbit Anti-GCNT3 Polyclonal Antibody – Cat# MBS3206915

Western Blot (WB) of anti-GCNT3 antibody

WB Suggested Anti-GCNT3 Antibody Titration: 1.25ug/ml
Positive Control: 293T cells lysate
Rabbit Anti-GCNT3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3206915

Other Notes

Small volumes of anti-GCNT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GCNT3 purchase

MBS3206915 is an antibody targeting GCNT3. Also known as GCNT3 antibody - C-terminal region. Reactive in Tested Species Reactivity: Human
Predicted Species Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep, Yeast. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GCNT3. It may not necessarily be applicable to this product.

NCBI GI #
4758422
NCBI GeneID
9245
NCBI Accession #
NP_004742
UniProt Primary Accession #
O95395
UniProt Related Accession #
O95395
GenBank Nucleotide #
NM_004751
NCBI Official Full Name
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
NCBI Official Synonym Full Names
glucosaminyl (N-acetyl) transferase 3, mucin type
NCBI Official Symbol
GCNT3
NCBI Official Synonym Symbols
GNTM; C24GNT; C2GNT2; C2GNTM; C2/4GnT
UniProt Protein Name
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3
UniProt Synonym Protein Names
C2GnT-mucin type; C2GnT-M; hC2GnT-M; Core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase
Protein Family
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase
UniProt Gene Name
GCNT3
UniProt Synonym Gene Names
C2GnT-M; hC2GnT-M; C2/4GnT
UniProt Entry Name
GCNT3_HUMAN
NCBI Protein Information
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

NCBI Summary for GCNT3

This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]

UniProt Comments for GCNT3

GCNT3: Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. Belongs to the glycosyltransferase 14 family.

Protein type: EC 2.4.1.150; Transferase; EC 2.4.1.102; Membrane protein, integral; Glycan Metabolism - O-glycan biosynthesis

Chromosomal Location of Human Ortholog: 15q21.3

Cellular Component: Golgi membrane; membrane; integral to membrane

Molecular Function: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; tissue morphogenesis; O-glycan processing; immunoglobulin production in mucosal tissue; carbohydrate metabolic process; post-translational protein modification; intestinal absorption
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Research Articles on GCNT3

1. High GCNT3 expression is associated with metastatic melanomas.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GCNT3 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mucin Type O-Glycan Biosynthesis Pathway antibodies  Mucin Type O-Glycan Biosynthesis Pathway Diagram
 Mucin Type O-Glycan Biosynthesis Pathway antibodies  Mucin Type O-Glycan Biosynthesis Pathway Diagram
 O-glycan Biosynthesis, Mucin Type Core Pathway antibodies  O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
 O-glycan Biosynthesis, Mucin Type Core Pathway antibodies  O-glycan Biosynthesis, Mucin Type Core Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram

Diseases associated with anti-GCNT3 antibody

 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >2 publications with GCNT3 and Hyperplasia
 Lung Diseases Antibodies  >1 publications with GCNT3 and Lung Diseases
 Immune System Diseases Antibodies  >1 publications with GCNT3 and Immune System Diseases

Organs/Tissues associated with anti-GCNT3 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >2 publications with GCNT3 and Intestine
 Eye Antibodies  >1 publications with GCNT3 and Eye
 Lung Antibodies  >1 publications with GCNT3 and Lung
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