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PCSK5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3206917

This is a rabbit polyclonal antibody against PCSK5. It was validated on Western Blot using a cell lysate as a positive control.Target Description: PCSK5 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
PCSK5, Polyclonal Antibody
Full Product Name
PCSK5 antibody - middle region
Product Gene Name
Product Synonym Gene Name
PC5; PC6; PC6A; SPC6
Immunogen Sequence
Synthetic peptide located within the following region: CAGAGADGCI NCTEGYFMED GRCVQSCSIS YYFDHSSENG YKSCKKCDIS
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Horse, Human, Mouse, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
PCSK5 peptide (MBS3231881) is used for blocking the activity of PCSK5 antibody (MBS3206917)
Molecular Weight
89kDa
3D Structure
ModBase 3D Structure for Q92824
Homology
Cow: 100%; Dog: 100%; Horse: 93%; Human: 100%; Mouse: 86%; Rabbit: 93%; Rat: 79%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human PCSK5

Product Categories/Family for anti-PCSK5 antibody

Applications Tested/Suitable for anti-PCSK5 antibody
Western Blot (WB)

Western Blot (WB) of anti-PCSK5 antibody

WB Suggested Anti-PCSK5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 293T cell lysatePCSK5 is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells
Rabbit Anti-PCSK5 Polyclonal Antibody – Cat# MBS3206917

Other Notes

Small volumes of anti-PCSK5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PCSK5 purchase

MBS3206917 is an antibody targeting PCSK5. Also known as PCSK5 antibody - middle region. Reactive in Cow, Dog, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PCSK5. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
proprotein convertase subtilisin/kexin type 5 isoform PC6A preproprotein
NCBI Official Synonym Full Names
proprotein convertase subtilisin/kexin type 5
NCBI Official Symbol
PCSK5
NCBI Official Synonym Symbols
PC5; PC6; PC6A; SPC6
UniProt Protein Name
Proprotein convertase subtilisin/kexin type 5
UniProt Synonym Protein Names
Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; hPC6; Subtilisin/kexin-like protease PC5
UniProt Gene Name
PCSK5
UniProt Synonym Gene Names
PC5; PC6; PC5; PC6; hPC6
NCBI Protein Information
proprotein convertase subtilisin/kexin type 5

NCBI Summary for PCSK5

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
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UniProt Comments for PCSK5

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PCSK5 antibody

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