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SLC40A1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3207124

This is a rabbit polyclonal antibody against SLC40A1. It was validated on Western BlotTarget Description: The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are… More details

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Product Overview

Online Datasheet in PDF
Product Name
SLC40A1, Polyclonal Antibody
Full Product Name
SLC40A1 antibody - middle region
Product Gene Name
anti-SLC40A1 antibody
Product Synonym Gene Name
FPN1; HFE4; IREG1; MST079; MSTP079; MTP1; SLC11A3
Immunogen Sequence
Synthetic peptide located within the following region: GSPLDLSVSP FEDIRSRFIQ GESITPTKIP EITTEIYMSN GSNSANIVPE
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
SLC40A1 peptide (MBS3232090) is used for blocking the activity of SLC40A1 antibody (MBS3207124)
Molecular Weight
62kDa
OMIM
604653
3D Structure
ModBase 3D Structure for Q9NP59
Homology
Cow: 93%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 86%; Rabbit: 100%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human SLC40A1

Product Categories/Family for anti-SLC40A1 antibody

Polyclonal; Ion Channel; Membrane & Traffic; Cell Structure
Applications Tested/Suitable for anti-SLC40A1 antibody
Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-SLC40A1 antibody

Rabbit Anti-SLC40A1 Antibody
Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue
Observed Staining: Plasma membrane in intercalated disk
Primary Antibody Concentration: 1:100
Other Working Concentrations: N/A
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
Rabbit Anti-SLC40A1 Polyclonal Antibody – Cat# MBS3207124

Western Blot (WB) of anti-SLC40A1 antibody

WB Suggested Anti-SLC40A1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
Rabbit Anti-SLC40A1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3207124

Other Notes

Small volumes of anti-SLC40A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLC40A1 purchase

MBS3207124 is an antibody targeting SLC40A1. Also known as SLC40A1 antibody - middle region. Reactive in Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC40A1. It may not necessarily be applicable to this product.

NCBI GI #
7657100
NCBI GeneID
30061
NCBI Accession #
NP_055400
UniProt Primary Accession #
Q9NP59
UniProt Related Accession #
Q9NP59
GenBank Nucleotide #
NM_014585
NCBI Official Full Name
solute carrier family 40 member 1
NCBI Official Synonym Full Names
solute carrier family 40 member 1
NCBI Official Symbol
SLC40A1
NCBI Official Synonym Symbols
FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3
UniProt Protein Name
Solute carrier family 40 member 1
UniProt Synonym Protein Names
Ferroportin-1; Iron-regulated transporter 1
UniProt Gene Name
SLC40A1
UniProt Synonym Gene Names
FPN1; IREG1; SLC11A3
UniProt Entry Name
S40A1_HUMAN
NCBI Protein Information
solute carrier family 40 member 1

NCBI Summary for SLC40A1

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

UniProt Comments for SLC40A1

SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: multivesicular body; synaptic vesicle; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane; intracellular

Molecular Function: protein binding; iron ion transmembrane transporter activity

Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport; lymphocyte homeostasis; negative regulation of apoptosis

Disease: Hemochromatosis, Type 4
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Research Articles on SLC40A1

1. Ca(2+) is required for human Fpn transport activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLC40A1 antibody

 Reference Product  PubMed Publications
 HFE antibody  >52 publications with SLC40A1 and HFE
 HAMP antibody  >42 publications with SLC40A1 and HAMP
 TFR2 antibody  >36 publications with SLC40A1 and TFR2
 HFE2 antibody  >10 publications with SLC40A1 and HFE2
 SLC11A2 antibody  >6 publications with SLC40A1 and SLC11A2
 HEPH antibody  >1 publications with SLC40A1 and HEPH

Pathways associated with anti-SLC40A1 antibody

 Products by Pathway  Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Metal Ion SLC Transporters Pathway antibodies  Metal Ion SLC Transporters Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram

Diseases associated with anti-SLC40A1 antibody

 Disease Name  Pubmed Publications
 Iron Overload Antibodies  >70 publications with SLC40A1 and Iron Overload
 Hemochromatosis Antibodies  >61 publications with SLC40A1 and Hemochromatosis
 Anemia Antibodies  >17 publications with SLC40A1 and Anemia
 Liver Diseases Antibodies  >15 publications with SLC40A1 and Liver Diseases
 Inflammation Antibodies  >6 publications with SLC40A1 and Inflammation
 Fibrosis Antibodies  >4 publications with SLC40A1 and Fibrosis
 Breast Neoplasms Antibodies  >3 publications with SLC40A1 and Breast Neoplasms
 Fatty Liver Antibodies  >2 publications with SLC40A1 and Fatty Liver
 Cardiovascular Diseases Antibodies  >2 publications with SLC40A1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with SLC40A1 and Heart Diseases

Organs/Tissues associated with anti-SLC40A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >46 publications with SLC40A1 and Blood
 Liver Antibodies  >36 publications with SLC40A1 and Liver
 Heart Antibodies  >7 publications with SLC40A1 and Heart
 Spleen Antibodies  >6 publications with SLC40A1 and Spleen
 Bone Antibodies  >6 publications with SLC40A1 and Bone
 Intestine Antibodies  >6 publications with SLC40A1 and Intestine
 Kidney Antibodies  >6 publications with SLC40A1 and Kidney
 Brain Antibodies  >5 publications with SLC40A1 and Brain
 Muscle Antibodies  >5 publications with SLC40A1 and Muscle
 Lung Antibodies  >3 publications with SLC40A1 and Lung
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