EPOR Antibody – Rabbit Polyclonal

EPOR: erythropoietin receptor: a member of the cytokine receptor family. Mediates erythropoietin-induced erythroblast proliferation, differentiation and survival. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. Forms homodimers on EPO stimulation. Tyrosine-phosphorylated EpoR may bind several SH2 domain-containing proteins including LYN, the adapter protein APS, SHP-1, SHP-2, JAK2, PI3 kinases, STAT5A/B, SOCS3, and CRKL. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Three alternatively-spliced isoforms have been described. Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling.

Protein type: Receptor, cytokine; Membrane protein, integral

Cellular Component: membrane; cell; extracellular region; integral to membrane; plasma membrane; cytosol

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; identical protein binding; protein binding; transmembrane receptor activity; erythropoietin receptor activity

Biological Process: heart morphogenesis; elevation of cytosolic calcium ion concentration; embryonic development; viral reproduction; heart development; cardiac muscle morphogensis; ventricular cardiac muscle morphogenesis; negative regulation of neuron apoptosis; brain development; decidualization; signal transduction