Rabbit Anti-SYNE4 Polyclonal Antibody – Cat# MBS3207581

WB Suggested Anti-C19orf46 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: 293T cell lysate

C19orf46 (SYNE4) Antibody – Rabbit Polyclonal

Name: SYNE4 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3207581
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3207581

This is a rabbit polyclonal antibody against C19orf46. It was validated on Western Blot using a cell lysate as a positive control.Target Description: The exact function of C19orf46 remains unknown. More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C19orf46 (SYNE4), Polyclonal Antibody

Full Product Name

C19orf46 antibody - N-terminal region

Product Gene Name

anti-SYNE4 antibody

Product Synonym Gene Name

FLJ36445; SYNE4; C19orf46

Immunogen Sequence

Synthetic peptide located within the following region: GEESTSPEQA QTLGQDSLGP PEHFQGGPRG NEPAAHPPRW STPSSYEDPA

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Horse, Human

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

C19orf46 peptide (MBS3232546) is used for blocking the activity of C19orf46 antibody (MBS3207581)

Molecular Weight

43kDa

3D Structure

ModBase 3D Structure for Q8N205

Homology

Cow: 85%; Horse: 85%; Human: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human C19orf46

Product Categories/Family for anti-SYNE4 antibody

Polyclonal; Membrane Protein

Applications Tested/Suitable for anti-SYNE4 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-SYNE4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SYNE4 purchase

MBS3207581 is an antibody targeting SYNE4. Also known as C19orf46 antibody - N-terminal region. Reactive in Cow, Horse, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SYNE4. It may not necessarily be applicable to this product.

NCBI GI #

89886475

NCBI GeneID

163183

NCBI Accession #

NP_001034965

UniProt Primary Accession #

Q8N205

UniProt Related Accession #

Q8N205

GenBank Nucleotide #

NM_001039876

NCBI Official Full Name

nesprin-4 isoform 1

NCBI Official Synonym Full Names

spectrin repeat containing nuclear envelope family member 4

NCBI Official Symbol

SYNE4

NCBI Official Synonym Symbols

KASH4; Nesp4; DFNB76; C19orf46

UniProt Protein Name

Nesprin-4

UniProt Synonym Protein Names

Nuclear envelope spectrin repeat protein 4

Protein Family

Nesprin

UniProt Gene Name

SYNE4

UniProt Synonym Gene Names

C19orf46

UniProt Entry Name

SYNE4_HUMAN

NCBI Protein Information

nesprin-4

NCBI Summary for SYNE4

This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

Research Articles on SYNE4

1. progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with hearing loss, encodes nesprin-4, a protein expressed in outer hair cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SYNE4 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with SYNE4 and Nervous System Diseases