Rabbit Anti-LTB Polyclonal Antibody – Cat# MBS3207708

Host: Rabbit
Target Name: LTB
Sample Tissue: Human Colorectal Tumor
Antibody Dilution: 1ug/ml

LTB Antibody – Rabbit Polyclonal

Name: LTB Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3207708
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3207708

This is a rabbit polyclonal antibody against LTB. It was validated on Western BlotTarget Description: Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LTB, Polyclonal Antibody

Full Product Name

LTB Antibody - C-terminal region

Product Gene Name

anti-LTB antibody

Immunogen Sequence

Synthetic peptide located within the following region: PELLLEGAET VTPVLDPARR QGYGPLWYTS VGFGGLVQLR RGERVYVNIS

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

LTB peptide (MBS3232674) is used for blocking the activity of LTB antibody (MBS3207708)

Molecular Weight

26kDa

OMIM

600978

3D Structure

ModBase 3D Structure for Q06643

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 100%; Rabbit: 100%; Rat: 93%

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human LTB

Product Categories/Family for anti-LTB antibody

Polyclonal; Membrane Protein; Cell Biology; Membrane & Traffic; Disease Related

Applications Tested/Suitable for anti-LTB antibody

Western Blot (WB)

Other Notes

Small volumes of anti-LTB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LTB purchase

MBS3207708 is an antibody targeting LTB. Also known as LTB Antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LTB. It may not necessarily be applicable to this product.

NCBI GI #

4505035

NCBI GeneID

4050

NCBI Accession #

NP_002332.1

UniProt Primary Accession #

Q06643

UniProt Related Accession #

Q06643

GenBank Nucleotide #

NM_002341.1

NCBI Official Full Name

lymphotoxin-beta isoform a

NCBI Official Synonym Full Names

lymphotoxin beta

NCBI Official Symbol

LTB

NCBI Official Synonym Symbols

p33; TNFC; TNFSF3; TNLG1C

UniProt Protein Name

Lymphotoxin-beta

UniProt Synonym Protein Names

Tumor necrosis factor C; TNF-C; Tumor necrosis factor ligand superfamily member 3

Protein Family

Lymphotoxin

UniProt Gene Name

LTB

UniProt Synonym Gene Names

TNFC; TNFSF3; LT-beta; TNF-C

UniProt Entry Name

TNFC_HUMAN

NCBI Protein Information

lymphotoxin-beta

NCBI Summary for LTB

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for LTB

LTB: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: extracellular space; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: skin development; positive regulation of interleukin-12 biosynthetic process; cell-cell signaling; gene expression; immune response; signal transduction; lymph node development

Research Articles on LTB

1. Combination of an EGFR tyrosine kinase inhibitor and a NF-kappaB inhibitor effectively suppressed cetuximab-resistant HNSCC and interfering with the EGFR-LTbeta interaction reverses resistance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LTB antibody

Reference Product	PubMed Publications
LTA antibody	>102 publications with LTB and LTA
LTBR antibody	>39 publications with LTB and LTBR
TNFSF14 antibody	>10 publications with LTB and TNFSF14
TNFRSF1A antibody	>3 publications with LTB and TNFRSF1A

Pathways associated with anti-LTB antibody

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Rheumatoid Arthritis Pathway antibodies	Rheumatoid Arthritis Pathway Diagram
Spinal Cord Injury Pathway antibodies	Spinal Cord Injury Pathway Diagram

Diseases associated with anti-LTB antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>402 publications with LTB and Inflammation
Necrosis Antibodies	>216 publications with LTB and Necrosis
Lung Diseases Antibodies	>172 publications with LTB and Lung Diseases
Neoplasms Antibodies	>76 publications with LTB and Neoplasms
Cardiovascular Diseases Antibodies	>73 publications with LTB and Cardiovascular Diseases
Edema Antibodies	>61 publications with LTB and Edema
Drug Toxicity Antibodies	>47 publications with LTB and Drug Toxicity
Atherosclerosis Antibodies	>31 publications with LTB and Atherosclerosis
Colitis Antibodies	>28 publications with LTB and Colitis
Brain Diseases Antibodies	>25 publications with LTB and Brain Diseases

Organs/Tissues associated with anti-LTB antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>624 publications with LTB and Blood
Spleen Antibodies	>71 publications with LTB and Spleen
Lymph Node Antibodies	>69 publications with LTB and Lymph Node
Lymph Antibodies	>66 publications with LTB and Lymph
Intestine Antibodies	>63 publications with LTB and Intestine
Bone Marrow Antibodies	>51 publications with LTB and Bone Marrow
Brain Antibodies	>37 publications with LTB and Brain
Embryonic Tissue Antibodies	>16 publications with LTB and Embryonic Tissue
Ovary Antibodies	>14 publications with LTB and Ovary
Connective Tissue Antibodies	>13 publications with LTB and Connective Tissue