Rabbit Anti-PI3 Polyclonal Antibody – Cat# MBS3207723

WB Suggested Anti-PI3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B cell lysate

PI3 Antibody – Rabbit Polyclonal

Name: PI3 Antibody; Polyclonal; Rabbit; Human/Pig-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3207723
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3207723

This is a rabbit polyclonal antibody against PI3. It was validated on Western Blot using a cell lysate as a positive control.Target Description: PI3 is an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PI3, Polyclonal Antibody

Full Product Name

PI3 antibody - middle region

Product Gene Name

anti-PI3 antibody

Product Synonym Gene Name

ESI; MGC13613; SKALP; WAP3; WFDC14; cementoin

Immunogen Sequence

Synthetic peptide located within the following region: KGRVPFNGQD PVKGQVSVKG QDKVKAQEPV KGPVSTKPGS CPIILIRCAM

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Human, Pig, Sheep

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

PI3 peptide (MBS3232689) is used for blocking the activity of PI3 antibody (MBS3207723)

Molecular Weight

6kDa

OMIM

182257

3D Structure

ModBase 3D Structure for P19957

Homology

Cow: 85%; Human: 100%; Pig: 77%; Sheep: 77%

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human PI3

Product Categories/Family for anti-PI3 antibody

Polyclonal; Signal Proteins; Membrane Protein

Applications Tested/Suitable for anti-PI3 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-PI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PI3 purchase

MBS3207723 is an antibody targeting PI3. Also known as PI3 antibody - middle region. Reactive in Cow, Human, Pig, Sheep. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PI3. It may not necessarily be applicable to this product.

NCBI GI #

4505787

NCBI GeneID

5266

NCBI Accession #

NP_002629

UniProt Primary Accession #

P19957

UniProt Related Accession #

P19957

GenBank Nucleotide #

NM_002638

NCBI Official Full Name

elafin preproprotein

NCBI Official Synonym Full Names

peptidase inhibitor 3

NCBI Official Symbol

PI3

NCBI Official Synonym Symbols

ESI; WAP3; SKALP; WFDC14; cementoin

UniProt Protein Name

Elafin

UniProt Synonym Protein Names

Elastase-specific inhibitor; ESI; Peptidase inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-derived antileukoproteinase; SKALP; WAP four-disulfide core domain protein 14

Protein Family

Elafin

UniProt Gene Name

PI3

UniProt Synonym Gene Names

WAP3; WFDC14; ESI; PI-3; SKALP

UniProt Entry Name

ELAF_HUMAN

NCBI Protein Information

elafin

NCBI Summary for PI3

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]

UniProt Comments for PI3

elafin: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.

Protein type: Extracellular matrix; Inhibitor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: proteinaceous extracellular matrix

Molecular Function: endopeptidase inhibitor activity

Research Articles on PI3

1. Elafin decreased in active patients with inflammatory bowel disease and was negatively correlated with disease activity, suggesting that elafin may play a protective role

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PI3 antibody

Reference Product	PubMed Publications
AKT1 antibody	>472 publications with PI3 and AKT1
PTEN antibody	>322 publications with PI3 and PTEN
CTNNB1 antibody	>88 publications with PI3 and CTNNB1

Diseases associated with anti-PI3 antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>301 publications with PI3 and Necrosis
Inflammation Antibodies	>299 publications with PI3 and Inflammation
Nervous System Diseases Antibodies	>263 publications with PI3 and Nervous System Diseases
Breast Neoplasms Antibodies	>222 publications with PI3 and Breast Neoplasms
Disease Models, Animal Antibodies	>213 publications with PI3 and Disease Models, Animal
Gastrointestinal Diseases Antibodies	>139 publications with PI3 and Gastrointestinal Diseases
Cell Transformation, Neoplastic Antibodies	>136 publications with PI3 and Cell Transformation, Neoplastic
Lung Diseases Antibodies	>130 publications with PI3 and Lung Diseases
Atherosclerosis Antibodies	>89 publications with PI3 and Atherosclerosis
Neoplasms, Experimental Antibodies	>85 publications with PI3 and Neoplasms, Experimental

Organs/Tissues associated with anti-PI3 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1004 publications with PI3 and Blood
Muscle Antibodies	>710 publications with PI3 and Muscle
Brain Antibodies	>576 publications with PI3 and Brain
Lung Antibodies	>259 publications with PI3 and Lung
Prostate Antibodies	>123 publications with PI3 and Prostate
Skin Antibodies	>110 publications with PI3 and Skin
Intestine Antibodies	>95 publications with PI3 and Intestine
Ovary Antibodies	>65 publications with PI3 and Ovary
Adipose Tissue Antibodies	>65 publications with PI3 and Adipose Tissue
Thyroid Antibodies	>50 publications with PI3 and Thyroid