Rabbit Anti-PTN Polyclonal Antibody – Cat# MBS3207728

WB Suggested Anti-PTN Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: HepG2 cell lysate

PTN Antibody – Rabbit Polyclonal

Name: PTN Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3207728
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3207728

This is a rabbit polyclonal antibody against PTN. It was validated on Western BlotTarget Description: PTN is a heparin binding mitogenic protein. It has neurite extension activity. More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PTN, Polyclonal Antibody

Full Product Name

PTN antibody - C-terminal region

Product Gene Name

anti-PTN antibody

Product Synonym Gene Name

HARP; HBGF8; HBNF; NEGF1

Immunogen Sequence

Synthetic peptide located within the following region: NTALKTRTGS LKRALHNAEC QKTVTISKPC GKLTKPKPQA ESKKKKKEGK

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Tested Reactivity: Human
Predicted Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Concentration

Batch dependent within range: 100 ul at 0.5 - 1 mg/ml (lot specific)

Preparation and Storage

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

PTN peptide (MBS3232694) is used for blocking the activity of PTN antibody (MBS3207728)

Molecular Weight

19kDa

OMIM

162095

3D Structure

ModBase 3D Structure for P21246

Protein Size (# AA)

168 amino acids

Description of Target

PTN is a heparin binding mitogenic protein. It has neurite extension activity.

Protein
Interactions

NEK6; CYP2E1; UBQLN1; TSC22D1; BAG6; SGTA; UBQLN4; FEZ1; PTN; KPNB1; CHD3; BARD1; GPRASP2; PIAS4; GADD45G; PFDN1; GSK3B; TAF1D; C7orf25; MRPL44; DNAJB11; NUDT21; C11orf58; GADD45A; BCL2L1; SUPT7L; SPIN1; UTP3; NAP1L5; LUC7L2; HGH1; GIPC2; CRCT1; BCCIP; TX

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human PTN

Replacement Item

This antibody may replace item sc-1394 from Santa Cruz Biotechnology.

Predicted Homology Based on Immunogen Sequence

Cow: 93%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%

Product Categories/Family for anti-PTN antibody

Polyclonal; Neurobiology; Signal Proteins; Cell Cycle Proteins; Growth Factors & Hormones; Membrane Protein; Cell Biology; Membrane & Traffic; DNA/RNA/Protein Interactions

Other Notes

Small volumes of anti-PTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTN purchase

MBS3207728 is an antibody targeting PTN. Also known as PTN antibody - C-terminal region. Reactive in Tested Reactivity: Human
Predicted Reactivity: Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTN. It may not necessarily be applicable to this product.

NCBI GI #

4506281

NCBI GeneID

5764

NCBI Accession #

NP_002816

UniProt Primary Accession #

P21246

UniProt Related Accession #

P21246

GenBank Nucleotide #

NM_002825

NCBI Official Full Name

pleiotrophin isoform 1

NCBI Official Synonym Full Names

pleiotrophin

NCBI Official Symbol

PTN

NCBI Official Synonym Symbols

HARP; HBBM; HBNF; HBGF8; NEGF1; OSF-1; HB-GAM; HBGF-8; HBNF-1

UniProt Protein Name

Pleiotrophin

UniProt Synonym Protein Names

Heparin-binding brain mitogen; HBBM; Heparin-binding growth factor 8; HBGF-8; Heparin-binding growth-associated molecule; HB-GAM; Heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; Osteoblast-specific factor 1

Protein Family

Pleiotrophin

UniProt Gene Name

PTN

UniProt Synonym Gene Names

HBNF1; NEGF1; PTN; HBBM; HBGF-8; HB-GAM; HBNF-1; OSF-1

UniProt Entry Name

PTN_HUMAN

NCBI Protein Information

pleiotrophin

NCBI Summary for PTN

The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

UniProt Comments for PTN

PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 7q33

Cellular Component: extracellular space; endoplasmic reticulum

Molecular Function: heparin binding; growth factor activity; protein phosphatase inhibitor activity

Biological Process: nervous system development; positive regulation of cell division; positive regulation of cell proliferation; negative regulation of catalytic activity; learning; transmembrane receptor protein tyrosine phosphatase signaling pathway; bone mineralization

Research Articles on PTN

1. Molecular crosstalk between tumour-associated macrophages and glioma stem cells through PTN-PTPRZ1 paracrine signalling supports glioblastoma malignant growth.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTN antibody

Reference Product	PubMed Publications
ALK antibody	>23 publications with PTN and ALK
PTPRZ1 antibody	>18 publications with PTN and PTPRZ1
SDC3 antibody	>7 publications with PTN and SDC3
VEGFA antibody	>5 publications with PTN and VEGFA
SRC antibody	>4 publications with PTN and SRC
PTEN antibody	>3 publications with PTN and PTEN
SDC1 antibody	>3 publications with PTN and SDC1
KDR antibody	>2 publications with PTN and KDR

Pathways associated with anti-PTN antibody

Products by Pathway	Pathway Diagram
Syndecan-3-mediated Signaling Events Pathway antibodies	Syndecan-3-mediated Signaling Events Pathway Diagram

Diseases associated with anti-PTN antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>62 publications with PTN and Carcinoma
Brain Diseases Antibodies	>40 publications with PTN and Brain Diseases
Cardiovascular Diseases Antibodies	>26 publications with PTN and Cardiovascular Diseases
Breast Neoplasms Antibodies	>24 publications with PTN and Breast Neoplasms
Lung Neoplasms Antibodies	>20 publications with PTN and Lung Neoplasms
Drug Toxicity Antibodies	>15 publications with PTN and Drug Toxicity
Inflammation Antibodies	>12 publications with PTN and Inflammation
Necrosis Antibodies	>12 publications with PTN and Necrosis
Neoplasms, Experimental Antibodies	>12 publications with PTN and Neoplasms, Experimental
Carcinoma, Squamous Cell Antibodies	>11 publications with PTN and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-PTN antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>170 publications with PTN and Brain
Bone Antibodies	>62 publications with PTN and Bone
Vascular Antibodies	>57 publications with PTN and Vascular
Muscle Antibodies	>54 publications with PTN and Muscle
Embryonic Tissue Antibodies	>33 publications with PTN and Embryonic Tissue
Lung Antibodies	>23 publications with PTN and Lung
Heart Antibodies	>20 publications with PTN and Heart
Skin Antibodies	>17 publications with PTN and Skin
Connective Tissue Antibodies	>17 publications with PTN and Connective Tissue
Kidney Antibodies	>15 publications with PTN and Kidney