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NR2F6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3207832

This is a rabbit polyclonal antibody against NR2F6. It was validated on Western Blot using a cell lysate as a positive control.Target Description: Orphan nuclear receptor EAR-2 (NR2F6, V-erbA related protein EAR-2 ) is predicted to be a protein similar in… More details

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Product Overview

Online Datasheet in PDF
Product Name
NR2F6, Polyclonal Antibody
Full Product Name
NR2F6 antibody - N-terminal region
Product Gene Name
anti-NR2F6 antibody
Product Synonym Gene Name
EAR-2; EAR2; ERBAL2
Immunogen Sequence
Synthetic peptide located within the following region: AGGYPRAAED DSASPPGAAS DAEPGDEERP GLQVDCVVCG DKSSGKHYGV
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
NR2F6 peptide (MBS3232797) is used for blocking the activity of NR2F6 antibody (MBS3207832)
Molecular Weight
43kDa
OMIM
132880
3D Structure
ModBase 3D Structure for P10588
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human NR2F6

Product Categories/Family for anti-NR2F6 antibody

Polyclonal; Transcription Factor; RNA Binding Proteins; Transcription Regulation; Chromatin & Nuclear Signaling; Receptors; Transcription Factors
Applications Tested/Suitable for anti-NR2F6 antibody
Western Blot (WB), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-NR2F6 antibody

NR2F6 antibody - N-terminal region

Formalin Fixed Paraffin Embedded Tissue: Human Liver Tissue

Observed Staining: Nucleus in hepatocytes

Primary Antibody Concentration: 1:100

Secondary Antibody: Donkey anti-Rabbit-Cy3

Secondary Antibody Concentration: 1:200

Magnification: 20X

Exposure Time: 0.5 - 2.0 sec
Rabbit Anti-NR2F6 Polyclonal Antibody – Cat# MBS3207832

Western Blot (WB) of anti-NR2F6 antibody

WB Suggested Anti-NR2F6 Antibody Titration: 0.2-1 ug/ml
Positive Control: HepG2 cell lysateNR2F6 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells
Rabbit Anti-NR2F6 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3207832

Other Notes

Small volumes of anti-NR2F6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR2F6 purchase

MBS3207832 is an antibody targeting NR2F6. Also known as NR2F6 antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NR2F6. It may not necessarily be applicable to this product.

NCBI GI #
20070199
NCBI GeneID
2063
NCBI Accession #
NP_005225
UniProt Primary Accession #
P10588
UniProt Related Accession #
P10588
GenBank Nucleotide #
NM_005234
NCBI Official Full Name
nuclear receptor subfamily 2 group F member 6
NCBI Official Synonym Full Names
nuclear receptor subfamily 2 group F member 6
NCBI Official Symbol
NR2F6
NCBI Official Synonym Symbols
EAR2; EAR-2; ERBAL2
UniProt Protein Name
Nuclear receptor subfamily 2 group F member 6
UniProt Synonym Protein Names
V-erbA-related protein 2
Protein Family
Nuclear receptor subfamily
UniProt Gene Name
NR2F6
UniProt Synonym Gene Names
EAR2; ERBAL2; EAR-2
UniProt Entry Name
NR2F6_HUMAN
NCBI Protein Information
nuclear receptor subfamily 2 group F member 6

UniProt Comments for NR2F6

EAR-2: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; neuron development; gene expression; steroid hormone mediated signaling; negative regulation of transcription from RNA polymerase II promoter; signal transduction; detection of temperature stimulus involved in sensory perception of pain; entrainment of circadian clock by photoperiod
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Research Articles on NR2F6

1. NR2F6 is an intracellular immune checkpoint that suppresses adaptive anti-cancer immune responses

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR2F6 antibody

 Reference Product  PubMed Publications
 NR2F2 antibody  >7 publications with NR2F6 and NR2F2

Pathways associated with anti-NR2F6 antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram

Diseases associated with anti-NR2F6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with NR2F6 and Neoplasms
 Immune System Diseases Antibodies  >3 publications with NR2F6 and Immune System Diseases
 Carcinoma Antibodies  >2 publications with NR2F6 and Carcinoma
 Brain Diseases Antibodies  >1 publications with NR2F6 and Brain Diseases
 Drug Toxicity Antibodies  >1 publications with NR2F6 and Drug Toxicity
 Cardiovascular Diseases Antibodies  >1 publications with NR2F6 and Cardiovascular Diseases
 Inflammation Antibodies  >1 publications with NR2F6 and Inflammation
 Hyperplasia Antibodies  >1 publications with NR2F6 and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with NR2F6 and Breast Neoplasms

Organs/Tissues associated with anti-NR2F6 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with NR2F6 and Brain
 Liver Antibodies  >3 publications with NR2F6 and Liver
 Nerve Antibodies  >2 publications with NR2F6 and Nerve
 Heart Antibodies  >1 publications with NR2F6 and Heart
 Bone Antibodies  >1 publications with NR2F6 and Bone
 Placenta Antibodies  >1 publications with NR2F6 and Placenta
 Testis Antibodies  >1 publications with NR2F6 and Testis
 Muscle Antibodies  >1 publications with NR2F6 and Muscle
 Kidney Antibodies  >1 publications with NR2F6 and Kidney
 Intestine Antibodies  >1 publications with NR2F6 and Intestine
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