Rabbit Anti-OSBPL1A Polyclonal Antibody – Cat# MBS3207851

WB Suggested Anti-OSBPL1A Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Small Intestine

OSBPL1A Antibody – Rabbit Polyclonal

Name: OSBPL1A Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3207851
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3207851

This is a rabbit polyclonal antibody against OSBPL1A. It was validated on Western Blot using a cell lysate as a positive control.Target Description: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

OSBPL1A, Polyclonal Antibody

Full Product Name

OSBPL1A antibody - middle region

Product Gene Name

anti-OSBPL1A antibody

Product Synonym Gene Name

FLJ10217; ORP-1; ORP1; OSBPL1B

Immunogen Sequence

Synthetic peptide located within the following region: EGEHLGSRKH RMSEEKDCGG GDALSNGIKK HRTSLPSPMF SRNDFSIWSI

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

OSBPL1A peptide (MBS3232816) is used for blocking the activity of OSBPL1A antibody (MBS3207851)

Molecular Weight

108kDa

OMIM

606730

3D Structure

ModBase 3D Structure for Q9BXW6

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human OSBPL1A

Product Categories/Family for anti-OSBPL1A antibody

Polyclonal; Drugs and Drug Metabolism; Various

Applications Tested/Suitable for anti-OSBPL1A antibody

Western Blot (WB)

Other Notes

Small volumes of anti-OSBPL1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OSBPL1A purchase

MBS3207851 is an antibody targeting OSBPL1A. Also known as OSBPL1A antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for OSBPL1A. It may not necessarily be applicable to this product.

NCBI GI #

19718741

NCBI GeneID

114876

NCBI Accession #

NP_542164

UniProt Primary Accession #

Q9BXW6

UniProt Related Accession #

Q9BXW6

GenBank Nucleotide #

NM_080597

NCBI Official Full Name

oxysterol-binding protein-related protein 1 isoform 2

NCBI Official Synonym Full Names

oxysterol binding protein like 1A

NCBI Official Symbol

OSBPL1A

NCBI Official Synonym Symbols

ORP1; ORP-1; OSBPL1B

UniProt Protein Name

Oxysterol-binding protein-related protein 1

Protein Family

Oxysterol-binding protein-related protein

UniProt Gene Name

OSBPL1A

UniProt Synonym Gene Names

ORP1; OSBP8; OSBPL1; OSBPL1B; ORP-1; OSBP-related protein 1

UniProt Entry Name

OSBL1_HUMAN

NCBI Protein Information

oxysterol-binding protein-related protein 1

NCBI Summary for OSBPL1A

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for OSBPL1A

OSBPL1A: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Belongs to the OSBP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 18q11.1

Cellular Component: nucleoplasm; lysosomal membrane; cytoplasm; late endosome; intracellular; nucleus

Molecular Function: protein binding; cholesterol binding; phospholipid binding

Biological Process: vesicle-mediated transport; cholesterol metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; lipid transport

Research Articles on OSBPL1A

1. ORP1L, via its liganding by lipids and the formation of contacts between autophagic vacuoles and the endoplasmic reticulum, governs the last steps in autophagy that lead to the lysosomal degradation of cytosolic material.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.