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CENPM Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3208158

This is a rabbit polyclonal antibody against CENPM. It was validated on Western Blot using a cell lysate as a positive control.Target Description: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
CENPM, Polyclonal Antibody
Full Product Name
CENPM antibody - middle region
Product Gene Name
anti-CENPM antibody
Product Synonym Gene Name
C22orf18; CENP-M; MGC861; PANE1; bK250D10.2
Immunogen Sequence
Synthetic peptide located within the following region: CDLEVEGFRA TMAQRLVRVL QICAGHVPGV SALNLLSLLR SSEGPSLEDL
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Horse, Human, Pig, Rabbit
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
CENPM peptide (MBS3233121) is used for blocking the activity of CENPM antibody (MBS3208158)
Molecular Weight
20kDa
OMIM
610152
3D Structure
ModBase 3D Structure for Q9NSP4
Homology
Cow: 79%; Dog: 79%; Horse: 93%; Human: 100%; Pig: 93%; Rabbit: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CENPM

Product Categories/Family for anti-CENPM antibody

Polyclonal; Chromatin & Nuclear Signaling; Epigenetics; Meiosis/Mitosis/Cell Cycle
Applications Tested/Suitable for anti-CENPM antibody
Immunofluorescence (IF), Western Blot (WB)

Immunofluorescence (IF) of anti-CENPM antibody

Sample Type : DNA/ACA
Rabbit Anti-CENPM Polyclonal Antibody – Cat# MBS3208158

Western Blot (WB) of anti-CENPM antibody

WB Suggested Anti-CENPM Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysate
Rabbit Anti-CENPM Polyclonal Antibody, Western Blot (WB) – Cat# MBS3208158

Other Notes

Small volumes of anti-CENPM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CENPM purchase

MBS3208158 is an antibody targeting CENPM. Also known as CENPM antibody - middle region. Reactive in Cow, Dog, Horse, Human, Pig, Rabbit. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CENPM. It may not necessarily be applicable to this product.

NCBI GI #
13129022
NCBI GeneID
79019
NCBI Accession #
NP_076958
UniProt Primary Accession #
Q9NSP4
UniProt Related Accession #
Q9NSP4
GenBank Nucleotide #
NM_024053
NCBI Official Full Name
centromere protein M isoform a
NCBI Official Synonym Full Names
centromere protein M
NCBI Official Symbol
CENPM
NCBI Official Synonym Symbols
PANE1; CENP-M; C22orf18
UniProt Protein Name
Centromere protein M
UniProt Synonym Protein Names
Interphase centromere complex protein 39; Proliferation-associated nuclear element protein 1
Protein Family
Centromere protein
UniProt Gene Name
CENPM
UniProt Synonym Gene Names
C22orf18; ICEN39; PANE1; CENP-M
UniProt Entry Name
CENPM_HUMAN
NCBI Protein Information
centromere protein M

NCBI Summary for CENPM

The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
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UniProt Comments for CENPM

CENPM: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; cytosol

Biological Process: nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle
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Research Articles on CENPM

1. CENP-M is crucially required for the assembly and stability of a tetramer also comprising CENP-I, CENP-H, and CENP-K, the HIKM complex, which we extensively characterize through a combination of structural, biochemical, and cell biological approaches.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CENPM antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway antibodies  Deposition Of New CENPA-containing Nucleosomes At The Centromere Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Nucleosome Assembly Pathway antibodies  Nucleosome Assembly Pathway Diagram
 Resolution Of Sister Chromatid Cohesion Pathway antibodies  Resolution Of Sister Chromatid Cohesion Pathway Diagram
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