ATP2A3 Antibody – Rabbit Polyclonal

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

ATP2A3: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Hydrolase; Endoplasmic reticulum; Transporter; Transporter, ion channel; EC 3.6.3.8; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; nuclear membrane; sarcoplasmic reticulum; endoplasmic reticulum; integral to membrane

Molecular Function: calcium-transporting ATPase activity; metal ion binding; ATP binding

Biological Process: transport; metabolic process; calcium ion transport; blood coagulation; transmembrane transport