Rabbit Anti-HAS3 Polyclonal Antibody – Cat# MBS3208256

WB Suggested Anti-HAS3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Hela cell lysate

HAS3 Antibody – Rabbit Polyclonal

Name: HAS3 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3208256
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3208256

This is a rabbit polyclonal antibody against HAS3. It was validated on Western Blot using a cell lysate as a positive control.Target Description: HAS3 is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HAS3, Polyclonal Antibody

Full Product Name

HAS3 antibody - N-terminal region

Product Gene Name

anti-HAS3 antibody

Immunogen Sequence

Synthetic peptide located within the following region: GQALKLPSPR RGSVALCIAA YQEDPDYLRK CLRSAQRISF PDLKVVMVVD

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

HAS3 peptide (MBS3233219) is used for blocking the activity of HAS3 antibody (MBS3208256)

Molecular Weight

63kDa

3D Structure

ModBase 3D Structure for O00219

Homology

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human HAS3

Product Categories/Family for anti-HAS3 antibody

Polyclonal; Signal Proteins; Membrane Protein; Drugs and Drug Metabolism

Applications Tested/Suitable for anti-HAS3 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-HAS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HAS3 purchase

MBS3208256 is an antibody targeting HAS3. Also known as HAS3 antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HAS3. It may not necessarily be applicable to this product.

NCBI GI #

20302153

NCBI GeneID

3038

NCBI Accession #

NP_005320

UniProt Primary Accession #

O00219

UniProt Related Accession #

O00219

GenBank Nucleotide #

NM_005329

NCBI Official Full Name

hyaluronan synthase 3 isoform a

NCBI Official Synonym Full Names

hyaluronan synthase 3

NCBI Official Symbol

HAS3

UniProt Protein Name

Hyaluronan synthase 3

UniProt Synonym Protein Names

Hyaluronate synthase 3; Hyaluronic acid synthase 3; HA synthase 3

Protein Family

Hyaluronan synthase

UniProt Gene Name

HAS3

UniProt Synonym Gene Names

HA synthase 3

NCBI Protein Information

hyaluronan synthase 3

NCBI Summary for HAS3

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

UniProt Comments for HAS3

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction ().

Research Articles on HAS3

1. Study shows that HAS3 is induced by IL-1beta in vascular smooth muscle cells and that HAS3 is critically involved in early macrophage driven inflammation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HAS3 antibody

Reference Product	PubMed Publications
CD44 antibody	>69 publications with HAS3 and CD44
HYAL2 antibody	>25 publications with HAS3 and HYAL2
HMMR antibody	>1 publications with HAS3 and HMMR

Pathways associated with anti-HAS3 antibody

Products by Pathway	Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
Hyaluronan Biosynthesis And Export Pathway antibodies	Hyaluronan Biosynthesis And Export Pathway Diagram
Hyaluronan Metabolism Pathway antibodies	Hyaluronan Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Carbohydrates Pathway antibodies	Metabolism Of Carbohydrates Pathway Diagram

Diseases associated with anti-HAS3 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>26 publications with HAS3 and Inflammation
Necrosis Antibodies	>17 publications with HAS3 and Necrosis
Skin Diseases Antibodies	>16 publications with HAS3 and Skin Diseases
Disease Models, Animal Antibodies	>14 publications with HAS3 and Disease Models, Animal
Adenocarcinoma Antibodies	>13 publications with HAS3 and Adenocarcinoma
Cardiovascular Diseases Antibodies	>9 publications with HAS3 and Cardiovascular Diseases
Ovarian Neoplasms Antibodies	>8 publications with HAS3 and Ovarian Neoplasms
Hyperplasia Antibodies	>8 publications with HAS3 and Hyperplasia
Lung Diseases Antibodies	>7 publications with HAS3 and Lung Diseases
Neoplasms, Experimental Antibodies	>6 publications with HAS3 and Neoplasms, Experimental

Organs/Tissues associated with anti-HAS3 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>14 publications with HAS3 and Lung
Connective Tissue Antibodies	>13 publications with HAS3 and Connective Tissue
Kidney Antibodies	>12 publications with HAS3 and Kidney
Prostate Antibodies	>11 publications with HAS3 and Prostate
Eye Antibodies	>9 publications with HAS3 and Eye
Embryonic Tissue Antibodies	>8 publications with HAS3 and Embryonic Tissue
Bladder Antibodies	>6 publications with HAS3 and Bladder
Mouth Antibodies	>5 publications with HAS3 and Mouth
Ovary Antibodies	>5 publications with HAS3 and Ovary
Intestine Antibodies	>4 publications with HAS3 and Intestine