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A4GALT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3208516

This is a rabbit polyclonal antibody against A4GALT. It was validated on Western Blot using a cell lysate as a positive control.Target Description: The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form… More details

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Product Overview

Online Datasheet in PDF
Product Name
A4GALT, Polyclonal Antibody
Full Product Name
A4GALT antibody - middle region
Product Gene Name
anti-A4GALT antibody
Product Synonym Gene Name
A14GALT; A4GALT1; P1; PK; Gb3S; P(k)
Immunogen Sequence
Synthetic peptide located within the following region: RIALMWKFGG IYLDTDFIVL KNLRNLTNVL GTQSRYVLNG AFLAFERRHE
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
A4GALT peptide (MBS3233478) is used for blocking the activity of A4GALT antibody (MBS3208516)
Molecular Weight
40kDa
OMIM
607922
3D Structure
ModBase 3D Structure for Q9NPC4
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human A4GALT

Product Categories/Family for anti-A4GALT antibody

Polyclonal; Signal Proteins; Membrane Protein
Applications Tested/Suitable for anti-A4GALT antibody
Western Blot (WB)

Western Blot (WB) of anti-A4GALT antibody

Host: Rabbit
Target Name: A4GALT
Sample Tissue: Human 293T Whole Cell
Antibody Dilution: 1ug/ml
Rabbit Anti-A4GALT Polyclonal Antibody – Cat# MBS3208516

Western Blot (WB) of anti-A4GALT antibody

WB Suggested Anti-A4GALT Antibody Titration: 0.2-1 ug/ml
Positive Control: THP-1 cell lysate
Rabbit Anti-A4GALT Polyclonal Antibody, Western Blot (WB) – Cat# MBS3208516

Other Notes

Small volumes of anti-A4GALT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A4GALT purchase

MBS3208516 is an antibody targeting A4GALT. Also known as A4GALT antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for A4GALT. It may not necessarily be applicable to this product.

NCBI GI #
8392830
NCBI GeneID
53947
NCBI Accession #
NP_059132
UniProt Primary Accession #
Q9NPC4
UniProt Related Accession #
Q9NPC4
GenBank Nucleotide #
NM_017436
NCBI Official Full Name
lactosylceramide 4-alpha-galactosyltransferase
NCBI Official Synonym Full Names
alpha 1,4-galactosyltransferase (P blood group)
NCBI Official Symbol
A4GALT
NCBI Official Synonym Symbols
P1; PK; Gb3S; P(k); P1PK; A14GALT; A4GALT1
UniProt Protein Name
Lactosylceramide 4-alpha-galactosyltransferase
UniProt Synonym Protein Names
Alpha-1,4-N-acetylglucosaminyltransferase; Alpha-1,4-galactosyltransferase; Alpha4Gal-T1; CD77 synthase; Globotriaosylceramide synthase; Gb3 synthase; P1/Pk synthase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
Protein Family
Lactosylceramide 4-alpha-galactosyltransferase
UniProt Gene Name
A4GALT
UniProt Synonym Gene Names
A14GALT; A4GALT1; Gb3 synthase
UniProt Entry Name
A4GAT_HUMAN
NCBI Protein Information
lactosylceramide 4-alpha-galactosyltransferase

NCBI Summary for A4GALT

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. This protein, a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
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UniProt Comments for A4GALT

A4GALT: Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins. Belongs to the glycosyltransferase 32 family.

Protein type: EC 2.4.1.228; Glycan Metabolism - glycosphingolipid biosynthesis - globo series; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: membrane; integral to Golgi membrane

Molecular Function: toxin binding; galactosyltransferase activity; lactosylceramide 4-alpha-galactosyltransferase activity

Biological Process: globoside biosynthetic process; glycosphingolipid biosynthetic process; plasma membrane organization and biogenesis; protein amino acid glycosylation

Disease: Blood Group, P1pk System
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Research Articles on A4GALT

1. The differential binding of transcription factor early growth response 1 to the SNP rs5751348 genomic region with the different genotypes in the A4GALT gene leads to differential activation of P(1) -A4GALT and P(2) -A4GALT expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-A4GALT antibody

 Products by Pathway  Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Glycosphingolipid Biosynthesis - Globo Series Pathway antibodies  Glycosphingolipid Biosynthesis - Globo Series Pathway Diagram
 Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway antibodies  Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway Diagram
 Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway antibodies  Glycosphingolipid Biosynthesis, Globo-series, LacCer => Gb4Cer Pathway Diagram

Diseases associated with anti-A4GALT antibody

 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >1 publications with A4GALT and Lymphoma

Organs/Tissues associated with anti-A4GALT antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with A4GALT and Bone
 Ovary Antibodies  >1 publications with A4GALT and Ovary
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