Rabbit Anti-CRACR2A Polyclonal Antibody – Cat# MBS3209006

WB Suggested Anti-EFCAB4B Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: NCI-H226 cell lysate

CRACR2A Antibody – Rabbit Polyclonal

Name: CRACR2A Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3209006
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3209006

This is a rabbit polyclonal antibody against EFCAB4B. It was validated on Western Blot using a cell lysate as a positive control. More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CRACR2A, Polyclonal Antibody

Full Product Name

CRACR2A Antibody - N-terminal region

Product Gene Name

anti-CRACR2A antibody

Product Synonym Gene Name

EFCAB4B

Immunogen Sequence

Synthetic peptide located within the following region: ARKDMQRLHK ELPLSLEELE DVFDALDADG NGYLTPQEFT TGFSHFFFSQ

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

CRACR2A peptide (MBS3233969) is used for blocking the activity of CRACR2A antibody (MBS3209006)

Molecular Weight

45kDa

OMIM

614178

3D Structure

ModBase 3D Structure for Q9BSW2

Homology

Cow: 79%; Dog: 86%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 92%; Rabbit: 79%; Rat: 85%; Zebrafish: 83%

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human EFCAB4B

Product Categories/Family for anti-CRACR2A antibody

Polyclonal

Applications Tested/Suitable for anti-CRACR2A antibody

Western Blot (WB)

Other Notes

Small volumes of anti-CRACR2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRACR2A purchase

MBS3209006 is an antibody targeting CRACR2A. Also known as CRACR2A Antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRACR2A. It may not necessarily be applicable to this product.

NCBI GI #

14249254

NCBI GeneID

84766

NCBI Accession #

NP_116069

UniProt Primary Accession #

Q9BSW2

UniProt Related Accession #

Q9BSW2

GenBank Nucleotide #

NM_032680

NCBI Official Full Name

EF-hand calcium-binding domain-containing protein 4B isoform c

NCBI Official Synonym Full Names

calcium release activated channel regulator 2A

NCBI Official Symbol

CRACR2A

NCBI Official Synonym Symbols

EFCAB4B

UniProt Protein Name

EF-hand calcium-binding domain-containing protein 4B

UniProt Synonym Protein Names

Calcium release-activated calcium channel regulator 2A; CRAC channel regulator 2A; Calcium release-activated channel regulator 2A

Protein Family

EF-hand calcium-binding domain-containing protein

UniProt Gene Name

CRACR2A

UniProt Synonym Gene Names

EFCAB4B; CRAC channel regulator 2A

UniProt Entry Name

EFC4B_HUMAN

NCBI Protein Information

EF-hand calcium-binding domain-containing protein 4B

UniProt Comments for CRACR2A

EFCAB4B: Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. Belongs to the EFCAB4 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 12p13.32

Cellular Component: Golgi apparatus; membrane; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; calcium ion binding

Biological Process: activation of store-operated calcium channel activity; immune system process; positive regulation of calcium ion transport

Research Articles on CRACR2A

1. Results show the characterization of CRACR2A protein which encodes a large Rab GTPase containing multiple functional domains contrary to small Rab GTPases. It was found to play an unexpected role in regulating intracellular signaling pathways important for T cell activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRACR2A antibody

Reference Product	PubMed Publications
STIM1 antibody	>4 publications with CRACR2A and STIM1
ORAI1 antibody	>4 publications with CRACR2A and ORAI1
ORAI3 antibody	>1 publications with CRACR2A and ORAI3

Diseases associated with anti-CRACR2A antibody

Disease Name	Pubmed Publications
Death Antibodies	>2 publications with CRACR2A and Death

Organs/Tissues associated with anti-CRACR2A antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with CRACR2A and Blood