Rabbit Anti-SRPRB Polyclonal Antibody – Cat# MBS3209552

WB Suggested Anti-SRPRB Antibody Titration: 5.0ug/ml
Positive Control: HepG2 cell lysate

SRPRB Antibody – Rabbit Polyclonal

Name: SRPRB Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS3209552
Price: 440 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3209552

This is a rabbit polyclonal antibody against SRPRB. It was validated on Western Blot using a cell lysate as a positive control.Target Description: SRPRB has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This… More details

$440 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SRPRB, Polyclonal Antibody

Full Product Name

SRPRB antibody - C-terminal region

Product Gene Name

anti-SRPRB antibody

Product Synonym Gene Name

APMCF1

Immunogen Sequence

Synthetic peptide located within the following region: APAQLGKKGK EFEFSQLPLK VEFLECSAKG GRGDVGSADI QDLEKWLAKI

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Protein A purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

SRPRB peptide (MBS3234509) is used for blocking the activity of SRPRB antibody (MBS3209552)

Molecular Weight

30kDa

3D Structure

ModBase 3D Structure for Q9Y5M8

Homology

Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 86%

Immunogen

The immunogen is a synthetic peptide directed towards the C terminal region of human SRPRB

Product Categories/Family for anti-SRPRB antibody

Polyclonal; Membrane Protein; Drugs and Drug Metabolism; Membrane & Traffic; Receptors

Applications Tested/Suitable for anti-SRPRB antibody

Western Blot (WB)

Other Notes

Small volumes of anti-SRPRB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SRPRB purchase

MBS3209552 is an antibody targeting SRPRB. Also known as SRPRB antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SRPRB. It may not necessarily be applicable to this product.

NCBI GI #

284795266

NCBI GeneID

58477

NCBI Accession #

NP_067026

UniProt Primary Accession #

Q9Y5M8

UniProt Related Accession #

Q9Y5M8

GenBank Nucleotide #

NM_021203

NCBI Official Full Name

signal recognition particle receptor subunit beta

NCBI Official Synonym Full Names

SRP receptor subunit beta

NCBI Official Symbol

SRPRB

NCBI Official Synonym Symbols

APMCF1

UniProt Protein Name

Signal recognition particle receptor subunit beta

UniProt Synonym Protein Names

Protein APMCF1

UniProt Gene Name

SRPRB

UniProt Synonym Gene Names

SR-beta

UniProt Entry Name

SRPRB_HUMAN

NCBI Protein Information

signal recognition particle receptor subunit beta

NCBI Summary for SRPRB

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]

UniProt Comments for SRPRB

SRPRB: Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR. Belongs to the SRP receptor beta subunit family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: endoplasmic reticulum membrane; membrane; cytoplasmic microtubule; cytoplasm; integral to membrane

Molecular Function: GTP binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; translation; unfolded protein response; small GTPase mediated signal transduction; gene expression

Research Articles on SRPRB

1. Results show that SRPRB promotes cell apoptosis through NF-kappaB activation. Its expression is regulated by SERP1 in pancreatic ductal adenocarcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SRPRB antibody

Products by Pathway	Pathway Diagram
Activation Of Chaperone Genes By XBP1(S) Pathway antibodies	Activation Of Chaperone Genes By XBP1(S) Pathway Diagram
Activation Of Chaperones By IRE1alpha Pathway antibodies	Activation Of Chaperones By IRE1alpha Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Protein Export Pathway antibodies	Protein Export Pathway Diagram
Protein Export Pathway antibodies	Protein Export Pathway Diagram
SRP-dependent Cotranslational Protein Targeting To Membrane Pathway antibodies	SRP-dependent Cotranslational Protein Targeting To Membrane Pathway Diagram
Translation Pathway antibodies	Translation Pathway Diagram
Unfolded Protein Response Pathway antibodies	Unfolded Protein Response Pathway Diagram

Diseases associated with anti-SRPRB antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>4 publications with SRPRB and Neoplasms
Liver Neoplasms Antibodies	>2 publications with SRPRB and Liver Neoplasms
Brain Diseases Antibodies	>1 publications with SRPRB and Brain Diseases
Liver Diseases Antibodies	>1 publications with SRPRB and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with SRPRB and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-SRPRB antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>2 publications with SRPRB and Liver
Brain Antibodies	>2 publications with SRPRB and Brain
Ovary Antibodies	>1 publications with SRPRB and Ovary
Lung Antibodies	>1 publications with SRPRB and Lung
Kidney Antibodies	>1 publications with SRPRB and Kidney
Amniotic Fluid Antibodies	>1 publications with SRPRB and Amniotic Fluid
Esophagus Antibodies	>1 publications with SRPRB and Esophagus
Stomach Antibodies	>1 publications with SRPRB and Stomach
Testis Antibodies	>1 publications with SRPRB and Testis