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NDST4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3209600

This is a rabbit polyclonal antibody against NDST4. It was validated on Western Blot using a cell lysate as a positive control.Target Description: NDST4 is an essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
NDST4, Polyclonal Antibody
Full Product Name
NDST4 antibody - N-terminal region
Product Gene Name
anti-NDST4 antibody
Product Synonym Gene Name
NDST-4; NHSST4
Immunogen Sequence
Synthetic peptide located within the following region: EDWTIFQYNH STYQPVLLTE LQTEKSLSSL SSKTLFATVI QDLGLHDGIQ
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
NDST4 peptide (MBS3234556) is used for blocking the activity of NDST4 antibody (MBS3209600)
Molecular Weight
101kDa
OMIM
615039
3D Structure
ModBase 3D Structure for Q9H3R1
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 90%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human NDST4

Product Categories/Family for anti-NDST4 antibody

Polyclonal; Signal Proteins; Membrane Protein
Applications Tested/Suitable for anti-NDST4 antibody
Western Blot (WB)

Western Blot (WB) of anti-NDST4 antibody

WB Suggested Anti-NDST4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: HepG2 cell lysateNDST4 is supported by BioGPS gene expression data to be expressed in HepG2
Rabbit Anti-NDST4 Polyclonal Antibody – Cat# MBS3209600

Other Notes

Small volumes of anti-NDST4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NDST4 purchase

MBS3209600 is an antibody targeting NDST4. Also known as NDST4 antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NDST4. It may not necessarily be applicable to this product.

NCBI GI #
12007650
NCBI GeneID
64579
NCBI Accession #
NP_072091
UniProt Primary Accession #
Q9H3R1
UniProt Related Accession #
Q9H3R1
GenBank Nucleotide #
NM_022569
NCBI Official Full Name
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
NCBI Official Synonym Full Names
N-deacetylase and N-sulfotransferase 4
NCBI Official Symbol
NDST4
NCBI Official Synonym Symbols
N-HSST; NDST-4; NHSST4; N-HSST 4
UniProt Protein Name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
UniProt Synonym Protein Names
Glucosaminyl N-deacetylase/N-sulfotransferase 4; NDST-4; N-heparan sulfate sulfotransferase 4
Protein Family
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase
UniProt Gene Name
NDST4
UniProt Synonym Gene Names
HSST4; NDST-4; N-HSST 4
UniProt Entry Name
NDST4_HUMAN
NCBI Protein Information
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4

UniProt Comments for NDST4

NDST4: Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity. Belongs to the sulfotransferase 1 family. NDST subfamily.

Protein type: EC 2.8.2.8; Glycan Metabolism - heparan sulfate biosynthesis; Hydrolase; Transferase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q26

Cellular Component: Golgi membrane; integral to membrane

Molecular Function: deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity

Biological Process: heparin biosynthetic process; heparan sulfate proteoglycan biosynthetic process
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Research Articles on NDST4

1. Highly-purified recombinant NDST-4 and a selective library of structurally-defined oligosaccharides were employed to determine the substrate specificity of rNDST-4. Full-length rNDST-4 lacks obvious N-deacetylase activity, and displays only N-sulfotransferase activity. NDST-4 did not show directional N-sulfotransferase activity while the N-deacetylase domain was inactive.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NDST4 antibody

 Products by Pathway  Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway antibodies  Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway Diagram
 Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway antibodies  Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway Diagram
 Heparan Sulfate Biosynthesis Pathway antibodies  Heparan Sulfate Biosynthesis Pathway Diagram
 Heparan Sulfate Biosynthesis Pathway antibodies  Heparan Sulfate Biosynthesis Pathway Diagram
 Heparan Sulfate Biosynthesis (late Stages) Pathway antibodies  Heparan Sulfate Biosynthesis (late Stages) Pathway Diagram
 Heparan Sulfate Biosynthesis (late Stages) Pathway antibodies  Heparan Sulfate Biosynthesis (late Stages) Pathway Diagram

Organs/Tissues associated with anti-NDST4 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with NDST4 and Lung
 Brain Antibodies  >1 publications with NDST4 and Brain
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