Rabbit Anti-CRYGC Polyclonal Antibody – Cat# MBS3210762

WB Suggested Anti-CRYGC Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: OVCAR-3 cell lysateCRYGC is supported by BioGPS gene expression data to be expressed in OVCAR3

CRYGC Antibody – Rabbit Polyclonal

Name: CRYGC Antibody; Polyclonal; Rabbit; Human/Rabbit/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3210762
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3210762

This is a rabbit polyclonal antibody against CRYGC. It was validated on Western Blot using a cell lysate as a positive control.Target Description: Crystallins are the dominant structural components of the vertebrate eye lens.Crystallins are separated into two… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CRYGC, Polyclonal Antibody

Full Product Name

CRYGC antibody - middle region

Product Gene Name

anti-CRYGC antibody

Product Synonym Gene Name

CCL; CRYG3

Immunogen Sequence

Synthetic peptide located within the following region: GLSDSIRSCC LIPQTVSHRL RLYEREDHKG LMMELSEDCP SIQDRFHLSE

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Cow, Dog, Horse, Human, Rabbit, Rat

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

CRYGC peptide (MBS3235716) is used for blocking the activity of CRYGC antibody (MBS3210762)

Molecular Weight

21kDa

OMIM

123680

3D Structure

ModBase 3D Structure for P07315

Homology

Cow: 79%; Dog: 93%; Horse: 86%; Human: 100%; Rabbit: 86%; Rat: 79%

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human CRYGC

Product Categories/Family for anti-CRYGC antibody

Polyclonal; Chromatin & Nuclear Signaling; Developmental Biology; E3 & Ubiquitin; Disease Related

Applications Tested/Suitable for anti-CRYGC antibody

Western Blot (WB)

Other Notes

Small volumes of anti-CRYGC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRYGC purchase

MBS3210762 is an antibody targeting CRYGC. Also known as CRYGC antibody - middle region. Reactive in Cow, Dog, Horse, Human, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRYGC. It may not necessarily be applicable to this product.

NCBI GI #

10518338

NCBI GeneID

1420

NCBI Accession #

NP_066269

UniProt Primary Accession #

P07315

UniProt Related Accession #

P07315

GenBank Nucleotide #

NM_020989

NCBI Official Full Name

gamma-crystallin C

NCBI Official Synonym Full Names

crystallin gamma C

NCBI Official Symbol

CRYGC

NCBI Official Synonym Symbols

CCL; CRYG3; CTRCT2

UniProt Protein Name

Gamma-crystallin C

UniProt Synonym Protein Names

Gamma-C-crystallin; Gamma-crystallin 2-1; Gamma-crystallin 3

Protein Family

Gamma-crystallin

UniProt Gene Name

CRYGC

UniProt Synonym Gene Names

CRYG3

UniProt Entry Name

CRGC_HUMAN

NCBI Protein Information

gamma-crystallin C

NCBI Summary for CRYGC

This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among others. [provided by RefSeq, Jan 2015]

UniProt Comments for CRYGC

CRYGC: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. Gamma-crystallins are involved in cataract formation.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 2q33.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; structural constituent of eye lens

Biological Process: camera-type eye development; visual perception

Disease: Cataract 2, Multiple Types

Research Articles on CRYGC

1. Study identified eight different mutations in CRYGC associated with autosomal dominant congenital nuclear cataracts (ADCC) in a cohort of Chinese family and shows that CRYGC mutations are responsible for 4.1% of ADCC families in the cohort. The results expand the spectrum of CRYGC mutations as well as their associated phenotypes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRYGC antibody

Reference Product	PubMed Publications
CRYAA antibody	>22 publications with CRYGC and CRYAA
CRYBB2 antibody	>15 publications with CRYGC and CRYBB2
CRYAB antibody	>13 publications with CRYGC and CRYAB
BFSP2 antibody	>5 publications with CRYGC and BFSP2

Diseases associated with anti-CRYGC antibody

Disease Name	Pubmed Publications
Cataract Antibodies	>45 publications with CRYGC and Cataract
Eye Abnormalities Antibodies	>3 publications with CRYGC and Eye Abnormalities

Organs/Tissues associated with anti-CRYGC antibody

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>29 publications with CRYGC and Eye