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BBS5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3211054

This is a rabbit polyclonal antibody against BBS5. It was validated on Western Blot using a cell lysate as a positive control.Target Description: BBS5 is a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
BBS5, Polyclonal Antibody
Full Product Name
BBS5 antibody - middle region
Product Gene Name
anti-BBS5 antibody
Immunogen Sequence
Synthetic peptide located within the following region: VEIDSDGHTD AFVAYFADGN KQQDREPVFS EELGLAIEKL KDGFTLQGLW
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
BBS5 peptide (MBS3236007) is used for blocking the activity of BBS5 antibody (MBS3211054)
Molecular Weight
39kDa
OMIM
603650
3D Structure
ModBase 3D Structure for Q8N3I7
Homology
Cow: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human BBS5

Product Categories/Family for anti-BBS5 antibody

Polyclonal
Applications Tested/Suitable for anti-BBS5 antibody
Western Blot (WB)

Western Blot (WB) of anti-BBS5 antibody

WB Suggested Anti-BBS5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 293T cell lysate
Rabbit Anti-BBS5 Polyclonal Antibody – Cat# MBS3211054

Other Notes

Small volumes of anti-BBS5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BBS5 purchase

MBS3211054 is an antibody targeting BBS5. Also known as BBS5 antibody - middle region. Reactive in Cow, Guinea Pig, Horse, Human, Mouse, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BBS5. It may not necessarily be applicable to this product.

NCBI GI #
22748823
NCBI GeneID
129880
NCBI Accession #
NP_689597
UniProt Primary Accession #
Q8N3I7
UniProt Related Accession #
Q8N3I7
GenBank Nucleotide #
NM_152384
NCBI Official Full Name
Bardet-Biedl syndrome 5 protein
NCBI Official Synonym Full Names
Bardet-Biedl syndrome 5
NCBI Official Symbol
BBS5
UniProt Protein Name
Bardet-Biedl syndrome 5 protein
Protein Family
Bardet-Biedl syndrome 5 protein
UniProt Gene Name
BBS5
NCBI Protein Information
Bardet-Biedl syndrome 5 protein

NCBI Summary for BBS5

This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is required for the formation of cilia. Alternate transcriptional splice variants have been observed but have not been fully characterized. [provided by RefSeq, Jul 2008]
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UniProt Comments for BBS5

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly.
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Research Articles on BBS5

1. The role of PITX2 in glaucoma may be mediated partly by regulating the expression of CXCL6 and BBS5 and thus affecting immune functions and intraocular pressure.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-BBS5 antibody

 Products by Pathway  Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 BBSome-mediated Cargo-targeting To Cilium Pathway antibodies  BBSome-mediated Cargo-targeting To Cilium Pathway Diagram
 Cargo Trafficking To The Periciliary Membrane Pathway antibodies  Cargo Trafficking To The Periciliary Membrane Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram

Diseases associated with anti-BBS5 antibody

 Disease Name  Pubmed Publications
 Bardet-Biedl Syndrome Antibodies  >32 publications with BBS5 and Bardet-Biedl Syndrome
 Hypertension Antibodies  >7 publications with BBS5 and Hypertension
 Heart Defects, Congenital Antibodies  >4 publications with BBS5 and Heart Defects, Congenital
 Cardiovascular Diseases Antibodies  >4 publications with BBS5 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with BBS5 and Kidney Diseases
 Musculoskeletal Abnormalities Antibodies  >2 publications with BBS5 and Musculoskeletal Abnormalities
 Hypercholesterolemia Antibodies  >1 publications with BBS5 and Hypercholesterolemia
 Embryo Loss Antibodies  >1 publications with BBS5 and Embryo Loss
 Vascular Diseases Antibodies  >1 publications with BBS5 and Vascular Diseases
 Fibrosis Antibodies  >1 publications with BBS5 and Fibrosis

Organs/Tissues associated with anti-BBS5 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >11 publications with BBS5 and Eye
 Heart Antibodies  >9 publications with BBS5 and Heart
 Brain Antibodies  >3 publications with BBS5 and Brain
 Lung Antibodies  >1 publications with BBS5 and Lung
 Connective Tissue Antibodies  >1 publications with BBS5 and Connective Tissue
 Testis Antibodies  >1 publications with BBS5 and Testis
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