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TTL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3211188

This is a rabbit polyclonal antibody against TTL. It was validated on Western Blot using a cell lysate as a positive control.Target Description: TTL catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
TTL, Polyclonal Antibody
Full Product Name
TTL antibody - middle region
Product Gene Name
Product Synonym Gene Name
MGC46235
Immunogen Sequence
Synthetic peptide located within the following region: LYREGVLRTA SEPYHVDNFQ DKTCHLTNHC IQKEYSKNYG KYEEGNEMFF
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
TTL peptide (MBS3236140) is used for blocking the activity of TTL antibody (MBS3211188)
Molecular Weight
43kDa
OMIM
608291
3D Structure
ModBase 3D Structure for Q8NG68
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human TTL
Applications Tested/Suitable for anti-TTL antibody
Western Blot (WB)

Western Blot (WB) of anti-TTL antibody

WB Suggested Anti-TTL Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human Lung
Rabbit Anti-TTL Polyclonal Antibody – Cat# MBS3211188

Other Notes

Small volumes of anti-TTL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TTL purchase

MBS3211188 is an antibody targeting TTL. Also known as TTL antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TTL. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
tubulin--tyrosine ligase
NCBI Official Synonym Full Names
tubulin tyrosine ligase
NCBI Official Symbol
TTL
UniProt Protein Name
Tubulin--tyrosine ligase
Protein Family
UniProt Gene Name
TTL
UniProt Synonym Gene Names
TTL
UniProt Entry Name
TTL_HUMAN
NCBI Protein Information
tubulin--tyrosine ligase

NCBI Summary for TTL

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]
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UniProt Comments for TTL

TTL: Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. Belongs to the tubulin--tyrosine ligase family.

Protein type: EC 6.3.2.25; Cell development/differentiation; Ligase

Chromosomal Location of Human Ortholog: 2q13

Molecular Function: tubulin-tyrosine ligase activity; ATP binding

Biological Process: protein modification process; regulation of axon extension; microtubule cytoskeleton organization and biogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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