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DDIT4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3213300

This is a rabbit polyclonal antibody against Ddit4. It was validated on Western BlotTarget Description: Ddit4 is a HIF-1-responsive gene that may protect some types of cells from hypoxia and H(2)O(2)-triggered apoptosis. More details

$490 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ddit4, Polyclonal Antibody
Full Product Name
Ddit4 Antibody - N-terminal region
Product Gene Name
anti-DDIT4 antibody
Product Synonym Gene Name
Rtp801
Immunogen Sequence
Synthetic peptide located within the following region: SLESSDCESL DSSNSGFGPE EDSSYLDGVS LPDFELLSDP EDEHLCANLM
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
Ddit4 peptide (MBS3238245) is used for blocking the activity of Ddit4 antibody (MBS3213300)
Molecular Weight
25kDa
3D Structure
ModBase 3D Structure for Q8VHZ9
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Rat Ddit4

Product Categories/Family for anti-DDIT4 antibody

Polyclonal; Apoptosis
Applications Tested/Suitable for anti-DDIT4 antibody
Western Blot (WB)

Western Blot (WB) of anti-DDIT4 antibody

Host: Rabbit
Target Name: Ddit4
Sample Type: Rat Thymus lysates
Antibody Dilution: 1.0ug/ml
Rabbit Anti-DDIT4 Polyclonal Antibody – Cat# MBS3213300

Other Notes

Small volumes of anti-DDIT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DDIT4 purchase

MBS3213300 is an antibody targeting DDIT4. Also known as Ddit4 Antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DDIT4. It may not necessarily be applicable to this product.

NCBI GI #
18376839
NCBI GeneID
140942
NCBI Accession #
NP_543182
UniProt Primary Accession #
Q8VHZ9
UniProt Related Accession #
Q8VHZ9
GenBank Nucleotide #
NM_080906
NCBI Official Full Name
DNA damage-inducible transcript 4 protein
NCBI Official Synonym Full Names
DNA-damage-inducible transcript 4
NCBI Official Symbol
Ddit4
NCBI Official Synonym Symbols
Rtp801
UniProt Protein Name
DNA damage-inducible transcript 4 protein
UniProt Synonym Protein Names
HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1; REDD-1
Protein Family
DNA damage-inducible transcript 4 protein
UniProt Gene Name
Ddit4
UniProt Synonym Gene Names
Redd1; Rtp801; REDD-1
NCBI Protein Information
DNA damage-inducible transcript 4 protein

NCBI Summary for DDIT4

HIF-1-responsive gene that may protect some types of cells from hypoxia and H(2)O(2)-triggered apoptosis [RGD, Feb 2006]

UniProt Comments for DDIT4

DDIT4: Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death. Up-regulated in fibroblasts upon ionizing radiation, via a TP53-dependent pathway. Up-regulated by TP63 in primary keratinocytes, and down-regulated during keratinocyte differentiation. Up-regulated upon DNA alkylation. Up-regulated by amyloid beta-peptide and retinoic acid. Up-regulated by hypoxia, via a PI3K and HIF1A-dependent but TP53/TP63-independent mechanism. Broadly expressed, with lowest levels in brain, skeletal muscle and intestine. Up-regulated in substantia nigra neurons from Parkinson disease patients. Belongs to the DDIT4 family.

Chromosomal Location of Human Ortholog: 20q11

Cellular Component: cytoplasm; cytosol; intracellular; mitochondrion

Biological Process: apoptosis; brain development; cell proliferation; defense response to virus; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of glycolytic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of TOR signaling; nerve growth factor receptor signaling pathway; neuron differentiation; neuron migration; protein complex disassembly; response to hypoxia
Show more

Research Articles on DDIT4

1. RTP801 is a novel downstream effector of mutant huntingtin -induced toxicity and that it may be relevant to the human disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DDIT4 antibody

 Products by Pathway  Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram

Diseases associated with anti-DDIT4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >25 publications with DDIT4 and Neoplasms
 Carcinoma Antibodies  >11 publications with DDIT4 and Carcinoma
 Nervous System Diseases Antibodies  >9 publications with DDIT4 and Nervous System Diseases
 Drug Toxicity Antibodies  >8 publications with DDIT4 and Drug Toxicity
 Brain Diseases Antibodies  >7 publications with DDIT4 and Brain Diseases
 Breast Neoplasms Antibodies  >6 publications with DDIT4 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >4 publications with DDIT4 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >4 publications with DDIT4 and Adenocarcinoma
 Leukemia Antibodies  >4 publications with DDIT4 and Leukemia
 Carcinoma, Hepatocellular Antibodies  >3 publications with DDIT4 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-DDIT4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with DDIT4 and Brain
 Liver Antibodies  >6 publications with DDIT4 and Liver
 Prostate Antibodies  >4 publications with DDIT4 and Prostate
 Heart Antibodies  >3 publications with DDIT4 and Heart
 Lung Antibodies  >3 publications with DDIT4 and Lung
 Kidney Antibodies  >2 publications with DDIT4 and Kidney
 Ovary Antibodies  >1 publications with DDIT4 and Ovary
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