Rabbit Anti-TRIM38 Polyclonal Antibody – Cat# MBS3213597

WB Suggested Anti-TRIM38 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: Human Liver

TRIM38 Antibody – Rabbit Polyclonal

Name: TRIM38 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3213597
Price: 490 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3213597

This is a rabbit polyclonal antibody against TRIM38. It was validated on Western BlotTarget Description: TRIM38 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2,… More details

$490 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TRIM38, Polyclonal Antibody

Full Product Name

TRIM38 antibody - middle region

Product Gene Name

anti-TRIM38 antibody

Product Synonym Gene Name

MGC8946; RNF15; RORET

Immunogen Sequence

Synthetic peptide located within the following region: LRSHQVSVTL DPDTAHHELI LSEDRRQVTR GYTQENQDTS SRRFTAFPCV

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Purity/Purification

Affinity Purified

Preparation and Storage

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

TRIM38 peptide (MBS3238538) is used for blocking the activity of TRIM38 antibody (MBS3213597)

Molecular Weight

53kDa

3D Structure

ModBase 3D Structure for O00635

Homology

Human: 100%

Immunogen

The immunogen is a synthetic peptide directed towards the middle region of human TRIM38

Product Categories/Family for anti-TRIM38 antibody

Polyclonal; Transcription Factor; Cancer; Lymphocyte Signaling; Cell Biology; DNA/RNA/Protein Interactions

Applications Tested/Suitable for anti-TRIM38 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-TRIM38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRIM38 purchase

MBS3213597 is an antibody targeting TRIM38. Also known as TRIM38 antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TRIM38. It may not necessarily be applicable to this product.

NCBI GI #

5454014

NCBI GeneID

10475

NCBI Accession #

NP_006346

UniProt Primary Accession #

O00635

UniProt Related Accession #

O00635

GenBank Nucleotide #

NM_006355

NCBI Official Full Name

E3 ubiquitin-protein ligase TRIM38

NCBI Official Synonym Full Names

tripartite motif containing 38

NCBI Official Symbol

TRIM38

NCBI Official Synonym Symbols

RNF15; RORET

UniProt Protein Name

Tripartite motif-containing protein 38

UniProt Synonym Protein Names

RING finger protein 15; Zinc finger protein RoRet

Protein Family

E3 ubiquitin-protein ligase

UniProt Gene Name

TRIM38

UniProt Synonym Gene Names

RNF15; RORET

UniProt Entry Name

TRI38_HUMAN

NCBI Protein Information

E3 ubiquitin-protein ligase TRIM38

NCBI Summary for TRIM38

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012]

UniProt Comments for TRIM38

TRIM38: E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. {ECO:0000269|PubMed:23056470}

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytosol

Molecular Function: signal transducer activity; zinc ion binding; ligase activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of viral genome replication; positive regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; positive regulation of transcription factor activity; regulation of interferon-beta production; negative regulation of defense response to virus; activation of NF-kappaB transcription factor

Research Articles on TRIM38

1. Data suggest that mRNA/protein levels of NLRP6 are down-regulated in synovial tissues and synoviocytes of rheumatoid arthritis (RA) patients compared to osteoarthritis patients; NLRP6 provides docking site to facilitate interaction between TAB2/3 and TRIM38 in RA synoviocytes in response to TNFalpha. (NLRP6 = ; TAB2/3 = transforming growth factor-b-activated kinase 1-binding protein 2/3; TRIM38 = tripartite motif 38)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TRIM38 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>1 publications with TRIM38 and Inflammation

Organs/Tissues associated with anti-TRIM38 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>1 publications with TRIM38 and Testis