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C2orf3 (GCFC2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3213732

This is a rabbit polyclonal antibody against C2orf3. It was validated on Western Blot using a cell lysate as a positive control.Target Description: The first mRNA transcript isolated for C2orf3 gene was part of an artificial chimera derived from two distinct… More details

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Product Overview

Online Datasheet in PDF
Product Name
C2orf3 (GCFC2), Polyclonal Antibody
Full Product Name
C2orf3 antibody - N-terminal region
Product Gene Name
anti-GCFC2 antibody
Product Synonym Gene Name
DNABF; GCF; TCF9; C2orf3
Immunogen Sequence
Synthetic peptide located within the following region: SEPDDHEKRI PFTLRPQTLR QRMAEESISR NEETSEESQE DEKQDTWEQQ
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
C2orf3 peptide (MBS3238672) is used for blocking the activity of C2orf3 antibody (MBS3213732)
Molecular Weight
89kDa
OMIM
189901
3D Structure
ModBase 3D Structure for P16383
Homology
Cow: 79%; Dog: 100%; Guinea Pig: 92%; Horse: 85%; Human: 100%; Mouse: 85%; Rabbit: 83%; Rat: 92%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human C2orf3

Product Categories/Family for anti-GCFC2 antibody

Polyclonal; Transcription Regulation; Various; Transcription Factors
Applications Tested/Suitable for anti-GCFC2 antibody
Western Blot (WB)

Western Blot (WB) of anti-GCFC2 antibody

Host: Rabbit
Target Name: GCFC2
Sample Type: Human Fetal Liver
Antibody Dilution: 1.0ug/ml
Rabbit Anti-GCFC2 Polyclonal Antibody – Cat# MBS3213732

Western Blot (WB) of anti-GCFC2 antibody

Host: Rabbit
Target Name: GCFC2
Sample Type: Jurkat
Antibody Dilution: 1.0ug/mlGCFC2 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells
Rabbit Anti-GCFC2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3213732

Western Blot (WB) of anti-GCFC2 antibody

WB Suggested Anti-C2orf3 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: Human Lung
Rabbit Anti-GCFC2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3213732

Other Notes

Small volumes of anti-GCFC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GCFC2 purchase

MBS3213732 is an antibody targeting GCFC2. Also known as C2orf3 antibody - N-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GCFC2. It may not necessarily be applicable to this product.

NCBI GI #
44890065
NCBI GeneID
6936
NCBI Accession #
NP_003194
UniProt Primary Accession #
P16383
UniProt Related Accession #
P16383
GenBank Nucleotide #
NM_003203
NCBI Official Full Name
GC-rich sequence DNA-binding factor 2 isoform 1
NCBI Official Synonym Full Names
GC-rich sequence DNA-binding factor 2
NCBI Official Symbol
GCFC2
NCBI Official Synonym Symbols
GCF; TCF9; DNABF; C2orf3
UniProt Protein Name
GC-rich sequence DNA-binding factor 2
UniProt Synonym Protein Names
GC-rich sequence DNA-binding factor; Transcription factor 9
Protein Family
GC-rich sequence DNA-binding factor
UniProt Gene Name
GCFC2
UniProt Synonym Gene Names
C2orf3; GCF; TCF9; TCF-9
UniProt Entry Name
GCFC2_HUMAN
NCBI Protein Information
GC-rich sequence DNA-binding factor 2

NCBI Summary for GCFC2

The first mRNA transcript isolated for this gene was part of an artificial chimera derived from two distinct gene transcripts and a primer used in the cloning process (see Genbank accession M29204). A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA, thus mistakenly thought to identify a transcription factor gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for GCFC2

TCF9: Factor that represses transcription. It binds to the GC- rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Belongs to the GCF family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: nucleoplasm; nucleolus; nucleus

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; spliceosome assembly; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
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Research Articles on GCFC2

1. Authors propose the GCF regulated transcriptional activity, at least in part, contributed to the upregulation of IER5 on radiation in HepG2 cells. The present findings provide insights into understanding the regulatory mechanisms of IER5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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