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JMJD5 (KDM8) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3213748

This is a rabbit polyclonal antibody against JMJD5. It was validated on Western Blot using a cell lysate as a positive control.Target Description: JMJD5 is a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
JMJD5 (KDM8), Polyclonal Antibody
Full Product Name
JMJD5 antibody - middle region
Product Gene Name
Product Synonym Gene Name
FLJ13798; JMJD5
Immunogen Sequence
Synthetic peptide located within the following region: KYRPIQTPSV CSDSLESPDE DMGSDSDVTT ESGSSPSHSP EERQDPGSAP
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
JMJD5 peptide (MBS3238688) is used for blocking the activity of JMJD5 antibody (MBS3213748)
Molecular Weight
47kDa
OMIM
611917
3D Structure
ModBase 3D Structure for Q8N371
Homology
Cow: 93%; Dog: 93%; Guinea Pig: 92%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 92%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human JMJD5
Applications Tested/Suitable for anti-KDM8 antibody
Chromatin IP (ChIP), Western Blot (WB)

Chromatin Immunoprecipitation (ChIP) of anti-KDM8 antibody

Chromatin Immunoprecipitation (ChIP) Using JMJD5 antibody - middle region and HCT116 Cells
Rabbit Anti-KDM8 Polyclonal Antibody – Cat# MBS3213748

Other Notes

Small volumes of anti-KDM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KDM8 purchase

MBS3213748 is an antibody targeting KDM8. Also known as JMJD5 antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KDM8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 2
NCBI Official Synonym Full Names
lysine demethylase 8
NCBI Official Symbol
KDM8
NCBI Official Synonym Symbols
JMJD5
UniProt Protein Name
Lysine-specific demethylase 8
UniProt Synonym Protein Names
JmjC domain-containing protein 5; Jumonji domain-containing protein 5
UniProt Gene Name
KDM8
UniProt Synonym Gene Names
JMJD5
UniProt Entry Name
KDM8_HUMAN
NCBI Protein Information
bifunctional peptidase and arginyl-hydroxylase JMJD5; jmjC domain-containing protein 5

NCBI Summary for KDM8

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

UniProt Comments for KDM8

JMJD5: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; EC 1.14.11.27; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: nucleus

Molecular Function: histone demethylase activity (H3-K36 specific); metal ion binding; chromatin binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KDM8 antibody

 Reference Product  PubMed Publications
 RCCD1 antibody  >1 publications with KDM8 and RCCD1

Diseases associated with anti-KDM8 antibody

Organs/Tissues associated with anti-KDM8 antibody

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