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MAGEL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3214557

This is a rabbit polyclonal antibody against MAGEL2. It was validated on Western BlotTarget Description: Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal… More details

$490 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
MAGEL2, Polyclonal Antibody
Full Product Name
MAGEL2 antibody - N-terminal region
Product Gene Name
Product Synonym Gene Name
NDNL1; nM15
Immunogen Sequence
Synthetic peptide located within the following region: MQGLFYRPQG SSKERRTSSK ERRAPSKDRM IFAATFCAPK AVSAARAHLP
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Human, Pig, Rabbit
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
MAGEL2 peptide (MBS3239494) is used for blocking the activity of MAGEL2 antibody (MBS3214557)
Molecular Weight
58kDa
OMIM
gene 615547
3D Structure
ModBase 3D Structure for Q9UJ55
Homology
Cow: 83%; Dog: 100%; Human: 100%; Pig: 88%; Rabbit: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human MAGEL2
Applications Tested/Suitable for anti-MAGEL2 antibody
Western Blot (WB)

Western Blot (WB) of anti-MAGEL2 antibody

WB Suggested Anti-MAGEL2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: A549 cell lysate
Rabbit Anti-MAGEL2 Polyclonal Antibody – Cat# MBS3214557

Other Notes

Small volumes of anti-MAGEL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAGEL2 purchase

MBS3214557 is an antibody targeting MAGEL2. Also known as MAGEL2 antibody - N-terminal region. Reactive in Cow, Dog, Human, Pig, Rabbit. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAGEL2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
MAGE-like protein 2
NCBI Official Synonym Full Names
MAGE family member L2
NCBI Official Symbol
MAGEL2
NCBI Official Synonym Symbols
PWLS; nM15; NDNL1; SHFYNG
UniProt Protein Name
MAGE-like protein 2
UniProt Synonym Protein Names
Necdin-like protein 1; Protein nM15
Protein Family
UniProt Gene Name
MAGEL2
UniProt Synonym Gene Names
NDNL1
UniProt Entry Name
MAGL2_HUMAN
NCBI Protein Information
MAGE-like protein 2

NCBI Summary for MAGEL2

Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq, Oct 2010]
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UniProt Comments for MAGEL2

MAGE-L2: May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Interacts with TRIM27

Chromosomal Location of Human Ortholog: 15q11.2

Cellular Component: retromer complex; early endosome; nucleus; endosome

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; retrograde transport, endosome to Golgi

Disease: Prader-willi Syndrome; Prader-willi-like Syndrome
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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