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HSD17B7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3215366

This is a rabbit polyclonal antibody against HSD17B7. It was validated on Western BlotTarget Description: HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a… More details

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Product Overview

Online Datasheet in PDF
Product Name
HSD17B7, Polyclonal Antibody
Full Product Name
HSD17B7 antibody - middle region
Product Gene Name
anti-HSD17B7 antibody
Product Synonym Gene Name
MGC12523; MGC75018; PRAP; SDR37C1
Immunogen Sequence
Synthetic peptide located within the following region: SDNPSQLIWT SSRSARKSNF SLEDFQHSKG KEPYSSSKYA TDLLSVALNR
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
HSD17B7 peptide (MBS3240270) is used for blocking the activity of HSD17B7 antibody (MBS3215366)
Molecular Weight
38kDa
OMIM
606756
3D Structure
ModBase 3D Structure for P56937
Homology
Cow: 93%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%

Product Categories/Family for anti-HSD17B7 antibody

Polyclonal; Drugs and Drug Metabolism; Various; Tissue Specific & Cell Marker
Applications Tested/Suitable for anti-HSD17B7 antibody
Western Blot (WB)

Western Blot (WB) of anti-HSD17B7 antibody

WB Suggested Anti-HSD17B7 Antibody
Titration: 1.0 ug/ml
Positive Control: PANC1 Whole CellHSD17B7 is supported by BioGPS gene expression data to be expressed in PANC1
Rabbit Anti-HSD17B7 Polyclonal Antibody – Cat# MBS3215366

Other Notes

Small volumes of anti-HSD17B7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSD17B7 purchase

MBS3215366 is an antibody targeting HSD17B7. Also known as HSD17B7 antibody - middle region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSD17B7. It may not necessarily be applicable to this product.

NCBI GI #
7705421
NCBI GeneID
51478
NCBI Accession #
NP_057455
UniProt Primary Accession #
P56937
UniProt Related Accession #
P56937
GenBank Nucleotide #
NM_016371
NCBI Official Full Name
3-keto-steroid reductase isoform 1
NCBI Official Synonym Full Names
hydroxysteroid 17-beta dehydrogenase 7
NCBI Official Symbol
HSD17B7
NCBI Official Synonym Symbols
PRAP; SDR37C1
UniProt Protein Name
3-keto-steroid reductase
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; Estradiol 17-beta-dehydrogenase 7
UniProt Gene Name
HSD17B7
UniProt Synonym Gene Names
17-beta-HSD 7
UniProt Entry Name
DHB7_HUMAN
NCBI Protein Information
3-keto-steroid reductase

NCBI Summary for HSD17B7

HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]

UniProt Comments for HSD17B7

Function: Responsible for the reduction of the keto group on the C-3 of sterols. Ref.11

Catalytic activity: A 3-beta-hydroxysteroid + NADP+ = a 3-oxosteroid + NADPH.17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.

Pathway: Steroid biosynthesis; estrogen biosynthesis.Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.

Subcellular location: Cell membrane; Single-pass membrane protein.

Tissue specificity: Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells.

Post-translational modification: Phosphorylated.

Sequence similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
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Research Articles on HSD17B7

1. Inhibition of 17beta-HSD 7 modulates breast cancer protein profile and enhances apoptosis by down-regulating GRP78.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSD17B7 antibody

 Reference Product  PubMed Publications
 CYP19A1 antibody  >10 publications with HSD17B7 and CYP19A1
 HSD17B1 antibody  >8 publications with HSD17B7 and HSD17B1
 CYP1B1 antibody  >2 publications with HSD17B7 and CYP1B1
 LSS antibody  >2 publications with HSD17B7 and LSS
 FDFT1 antibody  >1 publications with HSD17B7 and FDFT1

Pathways associated with anti-HSD17B7 antibody

 Products by Pathway  Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway antibodies  Cholesterol Biosynthesis, Squalene 2,3-epoxide => Cholesterol Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Steroid Biosynthesis Pathway antibodies  Steroid Biosynthesis Pathway Diagram

Diseases associated with anti-HSD17B7 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >5 publications with HSD17B7 and Breast Neoplasms
 Adenocarcinoma Antibodies  >3 publications with HSD17B7 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with HSD17B7 and Neoplasms, Experimental
 Liver Diseases Antibodies  >2 publications with HSD17B7 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with HSD17B7 and Liver Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with HSD17B7 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSD17B7 and Carcinoma, Hepatocellular
 Fetal Death Antibodies  >1 publications with HSD17B7 and Fetal Death
 Ovarian Diseases Antibodies  >1 publications with HSD17B7 and Ovarian Diseases
 Hypertrophy Antibodies  >1 publications with HSD17B7 and Hypertrophy

Organs/Tissues associated with anti-HSD17B7 antibody

 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >10 publications with HSD17B7 and Ovary
 Liver Antibodies  >8 publications with HSD17B7 and Liver
 Blood Antibodies  >7 publications with HSD17B7 and Blood
 Testis Antibodies  >4 publications with HSD17B7 and Testis
 Brain Antibodies  >4 publications with HSD17B7 and Brain
 Mammary Gland Antibodies  >3 publications with HSD17B7 and Mammary Gland
 Embryonic Tissue Antibodies  >3 publications with HSD17B7 and Embryonic Tissue
 Heart Antibodies  >3 publications with HSD17B7 and Heart
 Muscle Antibodies  >2 publications with HSD17B7 and Muscle
 Placenta Antibodies  >2 publications with HSD17B7 and Placenta
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