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ILKAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3215571

This is a rabbit polyclonal antibody against ILKAP. It was validated on Western BlotTarget Description: The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase… More details

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Product Overview

Online Datasheet in PDF
Product Name
ILKAP, Polyclonal Antibody
Full Product Name
ILKAP antibody - C-terminal region
Product Gene Name
anti-ILKAP antibody
Product Synonym Gene Name
DKFZp434J2031; FLJ10181; MGC4846; PP2C-DELTA; ILKAP2; ILKAP3
Immunogen Sequence
Synthetic peptide located within the following region: RRCQLTPNDR FILLACDGLF KVFTPEEAVN FILSCLEDEK IQTREGKSAA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity Purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
ILKAP peptide (MBS3240474) is used for blocking the activity of ILKAP antibody (MBS3215571)
Molecular Weight
43kDa
3D Structure
ModBase 3D Structure for Q9H0C8
Homology
Cow: 92%; Dog: 92%; Guinea Pig: 93%; Horse: 86%; Human: 100%; Mouse: 86%; Rabbit: 79%; Rat: 93%

Product Categories/Family for anti-ILKAP antibody

Polyclonal; Protein Kinases; Phosphorylation
Applications Tested/Suitable for anti-ILKAP antibody
Western Blot (WB)

Western Blot (WB) of anti-ILKAP antibody

WB Suggested Anti-ILKAP Antibody
Titration: 1.0 ug/ml
Positive Control: 721_B Whole CellILKAP is supported by BioGPS gene expression data to be expressed in 721_B
Rabbit Anti-ILKAP Polyclonal Antibody – Cat# MBS3215571

Other Notes

Small volumes of anti-ILKAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ILKAP purchase

MBS3215571 is an antibody targeting ILKAP. Also known as ILKAP antibody - C-terminal region. Reactive in Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ILKAP. It may not necessarily be applicable to this product.

NCBI GI #
13540531
NCBI GeneID
80895
NCBI Accession #
NP_110395
UniProt Primary Accession #
Q9H0C8
UniProt Related Accession #
Q9H0C8
GenBank Nucleotide #
NM_030768
NCBI Official Full Name
integrin-linked kinase-associated serine/threonine phosphatase 2C
NCBI Official Synonym Full Names
ILK associated serine/threonine phosphatase
NCBI Official Symbol
ILKAP
NCBI Official Synonym Symbols
PPM1O; ILKAP2; ILKAP3; PP2C-DELTA
UniProt Protein Name
Integrin-linked kinase-associated serine/threonine phosphatase 2C
Protein Family
Integrin-linked kinase-associated serine/threonine phosphatase
UniProt Gene Name
ILKAP
UniProt Synonym Gene Names
ILKAP
UniProt Entry Name
ILKAP_HUMAN
NCBI Protein Information
integrin-linked kinase-associated serine/threonine phosphatase 2C

NCBI Summary for ILKAP

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]
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UniProt Comments for ILKAP

ILKAP: a protein serine/threonine phosphatase of the PP2C family. Can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Protein type: Protein phosphatase, Ser/Thr (non-receptor); Motility/polarity/chemotaxis; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cytoplasm

Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: protein amino acid dephosphorylation; regulation of DNA replication during S phase
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Research Articles on ILKAP

1. ILKAP physically interacted with HIF-1A and induced its dephosphorylation. Both the HIF-1A-p53 interaction and apoptosis relied on ILKAP.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ILKAP antibody

 Reference Product  PubMed Publications
 ILK antibody  >4 publications with ILKAP and ILK

Diseases associated with anti-ILKAP antibody

 Disease Name  Pubmed Publications
 Ataxia Antibodies  >1 publications with ILKAP and Ataxia
 Nervous System Diseases Antibodies  >1 publications with ILKAP and Nervous System Diseases

Organs/Tissues associated with anti-ILKAP antibody

 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >2 publications with ILKAP and Mouth
 Blood Antibodies  >2 publications with ILKAP and Blood
 Prostate Antibodies  >1 publications with ILKAP and Prostate
 Kidney Antibodies  >1 publications with ILKAP and Kidney
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